IGSF8 explained

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.^{[1] [2] [3]} IGSF8 has also been designated as CD316 (cluster of differentiation 316).

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Charrin S, Le Naour F, Labas V, etal . EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. . Biochem. J. . 373 . Pt 2 . 409–21 . 2003 . 12708969 . 10.1042/BJ20030343 . 1223506 .
• Zhang XA, Lane WS, Charrin S, etal . EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. . Cancer Res. . 63 . 10 . 2665–74 . 2003 . 12750295 .
• Bonkobara M, Das A, Takao J, etal . Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. . Br. J. Dermatol. . 148 . 4 . 654–64 . 2003 . 12752121 . 10.1046/j.1365-2133.2003.05244.x . 21635573 .
• Stipp CS, Kolesnikova TV, Hemler ME . EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. . J. Cell Biol. . 163 . 5 . 1167–77 . 2004 . 14662754 . 10.1083/jcb.200309113 . 2173626 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kolesnikova TV, Stipp CS, Rao RM, etal . EWI-2 modulates lymphocyte integrin alpha4beta1 functions. . Blood . 103 . 8 . 3013–9 . 2004 . 15070678 . 10.1182/blood-2003-07-2201 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Yang XH, Kovalenko OV, Kolesnikova TV, etal . Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. . J. Biol. Chem. . 281 . 18 . 12976–85 . 2006 . 16537545 . 10.1074/jbc.M510617200 . free .
• Sala-Valdés M, Ursa A, Charrin S, etal . EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. . J. Biol. Chem. . 281 . 28 . 19665–75 . 2006 . 16690612 . 10.1074/jbc.M602116200 . free .
• Kettner S, Kalthoff F, Graf P, etal . EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells. . Mol. Cell. Biol. . 27 . 21 . 7718–26 . 2007 . 17785435 . 10.1128/MCB.00180-07 . 2169036 .

Notes and References

1. Stipp CS, Kolesnikova TV, Hemler ME . EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily . J Biol Chem . 276 . 44 . 40545–54 . Oct 2001 . 11504738 . 10.1074/jbc.M107338200 . free .
2. Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC . PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins . J Immunol . 167 . 9 . 5115–21 . Oct 2001 . 11673522 . 10.4049/jimmunol.167.9.5115. free .
3. Web site: Entrez Gene: IGSF8 immunoglobulin superfamily, member 8.