CD300LB (gene) explained

CD300 molecule like family member b is a protein that in humans is encoded by the CD300LB gene.^[1]

Function

CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008].

Further reading

• Martínez-Barriocanal A, Sayós J . Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways . J. Immunol. . 177 . 5 . 2819–30 . September 2006 . 16920917 . 10.4049/jimmunol.177.5.2819. free .
• Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VL, Takai T, Kitamura T . Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells . Blood . 111 . 2 . 688–98 . January 2008 . 17928527 . 10.1182/blood-2007-04-085787 . free .
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M . New genetic associations detected in a host response study to hepatitis B vaccine . Genes Immun. . 11 . 3 . 232–8 . April 2010 . 20237496 . 10.1038/gene.2010.1 . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Gasiorowski RE, Ju X, Hart DN, Clark GJ . CD300 molecule regulation of human dendritic cell functions . Immunol. Lett. . 149 . 1–2 . 93–100 . January 2013 . 23072861 . 10.1016/j.imlet.2012.10.005 .
• Voss OH, Murakami Y, Pena MY, Lee HN, Tian L, Margulies DH, Street JM, Yuen PS, Qi CF, Krzewski K, Coligan JE . Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock . Immunity . 44 . 6 . 1365–78 . June 2016 . 27261276 . 4917413 . 10.1016/j.immuni.2016.05.005 .

Notes and References

1. Web site: Entrez Gene: CD300 molecule like family member b. 2018-07-19.