CD300A explained

CD300A (Cluster of Differentiation 300A) is a human gene.^[1]

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM]^[2]

See also

• Cluster of differentiation

Further reading

• Clark GJ, Fitzpatrick S, Kuo B . CMRF-35A, CMRF-35H: potential new CD. . J. Biol. Regul. Homeost. Agents . 16 . 3 . 233–5 . 2003 . 12456026 . etal.
• Alvarez Y, Tang X, Coligan JE, Borrego F . The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. . Mol. Immunol. . 45 . 1 . 253–8 . 2007 . 17588661 . 10.1016/j.molimm.2007.05.006 . 2000843 .
• Bachelet I, Munitz A, Moretta A . The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. . J. Immunol. . 175 . 12 . 7989–95 . 2006 . 16339535 . 10.4049/jimmunol.175.12.7989. etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Clark GJ, Green BJ, Hart DN . The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. . Tissue Antigens . 55 . 2 . 101–9 . 2000 . 10746781 . 10.1034/j.1399-0039.2000.550201.x .
• Cantoni C, Bottino C, Augugliaro R . Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. . Eur. J. Immunol. . 29 . 10 . 3148–59 . 1999 . 10540326 . 10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L . etal. 8828216 .
• Green BJ, Clark GJ, Hart DN . The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. . Int. Immunol. . 10 . 7 . 891–9 . 1998 . 9701027 . 10.1093/intimm/10.7.891 .
• Jackson DG, Hart DN, Starling G, Bell JI . Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. . Eur. J. Immunol. . 22 . 5 . 1157–63 . 1992 . 1349532 . 10.1002/eji.1830220508 . 23437463 .

External links

• • CD300a, Bernholtz - The Possible End to Asthma - The Future of Things article

Notes and References

1. Web site: Entrez Gene: CD300A CD300a molecule.
2. Web site: Entrez Gene: CD300A CD300a molecule.