PSTPIP1 explained

Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.^{[1] [2]}

Interactions

PSTPIP1 has been shown to interact with:

• Abl gene^[3]
• BZW1^[4]
• CD2^[1]
• PTPN12^[5]
• PTPN18^[6]
• Wiskott–Aldrich syndrome protein^[7]

See also

• PAPA syndrome

Further reading

• Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA . PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase . J. Cell Biol. . 138 . 4 . 845–60 . 1997 . 9265651 . 2138048 . 10.1083/jcb.138.4.845 .
• Dowbenko D, Spencer S, Quan C, Lasky LA . Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein . J. Biol. Chem. . 273 . 2 . 989–96 . 1998 . 9422760 . 10.1074/jbc.273.2.989 . free .
• Wu Y, Spencer SD, Lasky LA . Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein . J. Biol. Chem. . 273 . 10 . 5765–70 . 1998 . 9488710 . 10.1074/jbc.273.10.5765 . free .
• Wu Y, Dowbenko D, Lasky LA . PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase . J. Biol. Chem. . 273 . 46 . 30487–96 . 1998 . 9804817 . 10.1074/jbc.273.46.30487 . free .
• Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP . Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation . Mol. Cell . 6 . 6 . 1413–23 . 2000 . 11163214 . 10.1016/S1097-2765(00)00138-6 . free .
• Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H . CrkL is an adapter for Wiskott–Aldrich syndrome protein and Syk . Blood . 97 . 9 . 2633–9 . 2001 . 11313252 . 10.1182/blood.V97.9.2633 . free .
• Côté JF, Chung PL, Théberge JF, Hallé M, Spencer S, Lasky LA, Tremblay ML . PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP . J. Biol. Chem. . 277 . 4 . 2973–86 . 2002 . 11711533 . 10.1074/jbc.M106428200 . free .
• Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, Lovett M . Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder . Hum. Mol. Genet. . 11 . 8 . 961–9 . 2002 . 11971877 . 10.1093/hmg/11.8.961 . free . 10.1.1.588.1632 .
• Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA . The Wiskott–Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse . Immunity . 18 . 1 . 141–54 . 2003 . 12530983 . 10.1016/S1074-7613(02)00516-2 . free .
• Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL . Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway . Proc. Natl. Acad. Sci. U.S.A. . 100 . 23 . 13501–6 . 2003 . 14595024 . 263843 . 10.1073/pnas.2135380100 . 2003PNAS..10013501S . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Baum W, Kirkin V, Fernández SB, Pick R, Lettau M, Janssen O, Zörnig M . Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL . J. Biol. Chem. . 280 . 48 . 40012–24 . 2005 . 16204241 . 10.1074/jbc.M502222200 . free .
• Yang H, Reinherz EL . CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST . J. Immunol. . 176 . 10 . 5898–907 . 2006 . 16670297 . 10.4049/jimmunol.176.10.5898 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL . A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion . EMBO J. . 17 . 24 . 7320–36 . February 1999 . 9857189 . 1171078 . 10.1093/emboj/17.24.7320 .
2. Web site: Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1.
3. Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP . Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation . Mol. Cell . 6 . 6 . 1413–23 . December 2000 . 11163214 . 10.1016/s1097-2765(00)00138-6. free .
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
5. Dowbenko D, Spencer S, Quan C, Lasky LA . Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein . J. Biol. Chem. . 273 . 2 . 989–96 . January 1998 . 9422760 . 10.1074/jbc.273.2.989. free .
6. Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA . PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase . J. Cell Biol. . 138 . 4 . 845–60 . August 1997 . 9265651 . 2138048 . 10.1083/jcb.138.4.845.
7. Wu Y, Spencer SD, Lasky LA . Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein . J. Biol. Chem. . 273 . 10 . 5765–70 . March 1998 . 9488710 . 10.1074/jbc.273.10.5765. free .