ATP1B3 explained

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.^{[1] [2]} ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.^[3]

Further reading

• Lingrel JB, Orlowski J, Shull MM, Price EM . Molecular genetics of Na,K-ATPase . Prog. Nucleic Acid Res. Mol. Biol. . 38 . 37–89 . 1990 . 2158121 . 10.1016/S0079-6603(08)60708-4 . Progress in Nucleic Acid Research and Molecular Biology . 978-0-12-540038-1 .
• Jørgensen PL . Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase . Biochim. Biophys. Acta . 694 . 1 . 27–68 . 1982 . 6289898 . 10.1016/0304-4157(82)90013-2.
• Chiampanichayakul S, Szekeres A, Khunkaewla P . Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation . Int. Immunol. . 14 . 12 . 1407–14 . 2003 . 12456588 . 10.1093/intimm/dxf112 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhang H, Li XJ, Martin DB, Aebersold R . Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry . Nat. Biotechnol. . 21 . 6 . 660–6 . 2003 . 12754519 . 10.1038/nbt827 . 581283 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Chi A, Valencia JC, Hu ZZ . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . J. Proteome Res. . 5 . 11 . 3135–44 . 2007 . 17081065 . 10.1021/pr060363j . etal.
• Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W . Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells . Tissue Antigens . 68 . 6 . 509–17 . 2007 . 17176442 . 10.1111/j.1399-0039.2006.00726.x .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Aughey RJ, Murphy KT, Clark SA . Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes . J. Appl. Physiol. . 103 . 1 . 39–47 . 2007 . 17446412 . 10.1152/japplphysiol.00236.2006 . 7370462 . etal.

Notes and References

1. Malik N, Canfield VA, Beckers MC, Gros P, Levenson R . Identification of the mammalian Na,K-ATPase 3 subunit . J Biol Chem . 271 . 37 . 22754–8 . Nov 1996 . 8798450 . 10.1074/jbc.271.37.22754 . free .
2. Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R . Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene . Mamm Genome . 9 . 2 . 136–43 . Mar 1998 . 9457675 . 10.1007/s003359900704 . 31228553 .
3. Web site: Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide.