Glutamyl aminopeptidase explained

glutamyl aminopeptidase (aminopeptidase A)
Hgncid:	3355
Symbol:	ENPEP
Altsymbols:	gp160, CD249
Entrezgene:	2028
Omim:	138297
Refseq:	NM_001977
Uniprot:	Q07075
Ecnumber:	3.4.11.7
Chromosome:	4
Arm:	q
Band:	25

Glutamyl aminopeptidase (aminopeptidase A, aspartate aminopeptidase, angiotensinase A, glutamyl peptidase, Ca²⁺-activated glutamate aminopeptidase, membrane aminopeptidase II, antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, angiotensinase A2) is an enzyme encoded by the gene. Glutamyl aminopeptidase has also recently been designated CD249 (cluster of differentiation 249).

Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.^[1]

External links

• The MEROPS online database for peptidases and their inhibitors: M01.003

Notes and References

1. Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C . Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure . Biochem. Soc. Trans. . 28 . 4 . 435–40 . 2000 . 10961935 . 10.1042/0300-5127:0280435 .