CD248 explained

Endosialin is a protein that in humans is encoded by the CD248 gene.^{[1] [2] [3]}

Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized. ^[4]

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.^[5]

See also

• Cluster of differentiation

Further reading

• Rettig WJ, Garin-Chesa P, Healey JH . Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. . Proc. Natl. Acad. Sci. U.S.A. . 89 . 22 . 10832–6 . 1992 . 1438285 . 10.1073/pnas.89.22.10832 . 50436 . 1992PNAS...8910832R . etal. free .
• Opavsky R, Haviernik P, Jurkovicova D . Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo. . J. Biol. Chem. . 276 . 42 . 38795–807 . 2001 . 11489895 . 10.1074/jbc.M105241200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Brady J, Neal J, Sadakar N, Gasque P . Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors. . J. Neuropathol. Exp. Neurol. . 63 . 12 . 1274–83 . 2005 . 15624764 . 10.1093/jnen/63.12.1274. free .
• MacFadyen JR, Haworth O, Roberston D . Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. . FEBS Lett. . 579 . 12 . 2569–75 . 2005 . 15862292 . 10.1016/j.febslet.2005.03.071 . 11757246 . etal. free .
• Dolznig H, Schweifer N, Puri C . Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. . Cancer Immun. . 5 . 10 . 2006 . 16076089 . etal.
• Tomkowicz B, Rybinski K, Foley B . Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 46 . 17965–70 . 2008 . 17986615 . 10.1073/pnas.0705647104 . 2084280 . etal. free .
• Khan KA, McMurray J, Mohammed FM, Bicknell R . C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation. . FEBS Journal . 286 . 17. 3299–3332 . 2019 . 31287944. 10.1111/febs.14985. 6852297 .

Notes and References

1. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW . Genes expressed in human tumor endothelium . Science . 289 . 5482 . 1197–202 . Aug 2000 . 10947988 . 10.1126/science.289.5482.1197 . 2000Sci...289.1197S .
2. Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC . Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium . J Biol Chem . 276 . 10 . 7408–14 . May 2001 . 11084048 . 10.1074/jbc.M009604200 . free .
3. Web site: Entrez Gene: CD248 CD248 molecule, endosialin.
4. Khan KA, McMurray J, Mohammed FM, Bicknell R . C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation. . FEBS Journal . 286 . 17. 3299–3332 . 2019 . 31287944. 10.1111/febs.14985. 6852297 .
5. Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P. Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. . Cancer Immun . 6 . 10 . 2006 . 16875435.