CD200R1 explained

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.^{[1] [2] [3]} CD200R1 is expressed on the surface of myeloid cells^[4] and CD4+ T cells.^[5] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,^[6] epithelial cells,^[7] endothelial cells,^[8] fibroblasts,^[9] and lymphoid cells.^[10]

CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),^[11] interferons, and inducible nitric oxide synthase (iNOS).^[12]

Function

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.^[3]

Further reading

• Matsue H . CD 200-mediated regulation of skin immunity . The Journal of Investigative Dermatology . 125 . 6 . x-xi . December 2005 . 16354172 . 10.1111/j.0022-202X.2005.23978.x . free .
• Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H . Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200 . Journal of Immunology . 175 . 7 . 4441–9 . October 2005 . 16177086 . 10.4049/jimmunol.175.7.4441 . free .
• Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH . The CD200 receptor is a novel and potent regulator of murine and human mast cell function . Journal of Immunology . 174 . 3 . 1348–56 . February 2005 . 15661892 . 10.4049/jimmunol.174.3.1348 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Science . 13 . 10 . 2819–24 . October 2004 . 15340161 . 2286551 . 10.1110/ps.04682504 .
• Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN . Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor . Journal of Virology . 78 . 14 . 7667–76 . July 2004 . 15220441 . 434103 . 10.1128/JVI.78.14.7667-7676.2004 .
• Karteris E, Chen J, Randeva HS . Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system . The Journal of Clinical Endocrinology and Metabolism . 89 . 4 . 1957–62 . April 2004 . 15070969 . 10.1210/jc.2003-031778 . free .
• Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN . Characterization of the CD200 receptor family in mice and humans and their interactions with CD200 . Journal of Immunology . 171 . 6 . 3034–46 . September 2003 . 12960329 . 10.4049/jimmunol.171.6.3034 . free .
• Vieites JM, de la Torre R, Ortega MA, Montero T, Peco JM, Sánchez-Pozo A, Gil A, Suárez A . Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13 . Gene . 311 . 99–104 . June 2003 . 12853143 . 10.1016/S0378-1119(03)00562-6 .

Notes and References

1. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN . Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function . Immunity . 13 . 2 . 233–42 . August 2000 . 10981966 . 10.1016/S1074-7613(00)00023-6 . free .
2. Dick AD, Broderick C, Forrester JV, Wright GJ . Distribution of OX2 antigen and OX2 receptor within retina . Investigative Ophthalmology & Visual Science . 42 . 1 . 170–6 . January 2001 . 11133863 .
3. Web site: Entrez Gene: CD200R1 CD200 receptor 1.
4. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN . Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function . Immunity . 13 . 2 . 233–42 . August 2000 . 10981966 . 10.1016/s1074-7613(00)00023-6. free .
5. Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R . Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells . PLOS ONE . 7 . 4 . e35466 . 2012 . 22496920 . 3322173 . 10.1371/journal.pone.0035466 . 2012PLoSO...735466C . free .
6. Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA . Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation . The Journal of Biological Chemistry . 286 . 40 . 34722–32 . October 2011 . 21835925 . 3186410 . 10.1074/jbc.M111.280826 . free .
7. Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL . Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? . The Journal of Investigative Dermatology . 123 . 5 . 880–7 . November 2004 . 15482475 . 10.1111/j.0022-202X.2004.23461.x . free .
8. Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH . Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions . Journal of Anatomy . 214 . 1 . 183–95 . January 2009 . 19166481 . 2667927 . 10.1111/j.1469-7580.2008.00986.x .
9. Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G . CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors . Scientific Reports . 7 . 46662 . April 2017 . 28429795 . 5399371 . 10.1038/srep46662 . 2017NatSR...746662I .
10. Gentry M, Bodo J, Durkin L, Hsi ED . Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma . The American Journal of Surgical Pathology . 41 . 2 . 189–194 . February 2017 . 27879516 . 10.1097/PAS.0000000000000771 . 25206581 .
11. Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P . CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells . PLOS ONE . 7 . 2 . e31671 . 2012 . 22363701 . 3282758 . 10.1371/journal.pone.0031671 . 2012PLoSO...731671P . free .
12. Carter DA, Dick AD . CD200 maintains microglial potential to migrate in adult human retinal explant model . Current Eye Research . 28 . 6 . 427–36 . June 2004 . 15512951 . 10.1080/02713680490503778 . 20846500 .