CD1E explained

T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.^{[1] [2]}

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Several alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined.

See also

• Cluster of differentiation

Further reading

• Brigl M, Brenner MB . CD1: antigen presentation and T cell function. . Annu. Rev. Immunol. . 22 . 1. 817–90 . 2004 . 15032598 . 10.1146/annurev.immunol.22.012703.104608 .
• Calabi F, Jarvis JM, Martin L, Milstein C . Two classes of CD1 genes. . Eur. J. Immunol. . 19 . 2 . 285–92 . 1989 . 2467814 . 10.1002/eji.1830190211 . 31384394 .
• Yu CY, Milstein C . A physical map linking the five CD1 human thymocyte differentiation antigen genes. . EMBO J. . 8 . 12 . 3727–32 . 1990 . 2583117 . 10.1002/j.1460-2075.1989.tb08548.x. 402056 .
• Albertson DG, Fishpool R, Sherrington P . Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. . EMBO J. . 7 . 9 . 2801–5 . 1988 . 3053166 . 10.1002/j.1460-2075.1988.tb03135.x. 457071 . etal.
• Martin LH, Calabi F, Milstein C . Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. . Proc. Natl. Acad. Sci. U.S.A. . 83 . 23 . 9154–8 . 1987 . 3097645 . 10.1073/pnas.83.23.9154 . 387093 . free .
• Adams MD, Kerlavage AR, Fleischmann RD . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 . etal.
• Han M, Hannick LI, DiBrino M, Robinson MA . Polymorphism of human CD1 genes. . Tissue Antigens . 54 . 2 . 122–7 . 2000 . 10488738 . 10.1034/j.1399-0039.1999.540202.x .
• Mirones I, Oteo M, Parra-Cuadrado JF, Martínez-Naves E . Identification of two novel human CD1E alleles. . Tissue Antigens . 56 . 2 . 159–61 . 2001 . 11019917 . 10.1034/j.1399-0039.2000.560208.x .
• Tamouza R, Sghiri R, Ramasawmy R . Two novel CD1 E alleles identified in black African individuals. . Tissue Antigens . 59 . 5 . 417–20 . 2003 . 12144626 . 10.1034/j.1399-0039.2002.590509.x . etal.
• Angénieux C, Salamero J, Fricker D . Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution. . Immunogenetics . 54 . 12 . 842–9 . 2003 . 12671734 . 10.1007/s00251-003-0538-0 . 2302966 . etal.
• Angénieux C, Fraisier V, Maître B . The cellular pathway of CD1e in immature and maturing dendritic cells. . Traffic . 6 . 4 . 286–302 . 2005 . 15752135 . 10.1111/j.1600-0854.2005.00272.x . 6199618 . etal. free .
• de la Salle H, Mariotti S, Angenieux C . Assistance of microbial glycolipid antigen processing by CD1e. . Science . 310 . 5752 . 1321–4 . 2005 . 16311334 . 10.1126/science.1115301 . 2005Sci...310.1321D . 20963542 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Caporale CM, Papola F, Fioroni MA . Susceptibility to Guillain–Barré syndrome is associated to polymorphisms of CD1 genes. . J. Neuroimmunol. . 177 . 1–2 . 112–8 . 2006 . 16820217 . 10.1016/j.jneuroim.2006.05.018 . 21604886 . etal.

Notes and References

1. Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H . Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells . J Biol Chem . 275 . 48 . 37757–64 . Dec 2000 . 10948205 . 10.1074/jbc.M007082200 . free .
2. Web site: Entrez Gene: CD1E CD1e molecule.