CD180 explained

CD180 antigen is a protein that in humans is encoded by the CD180 gene.^{[1] [2] [3]}

Notes and References

1. Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M . RP105 is associated with MD-1 and transmits an activation signal in human B cells . Blood . 92 . 8 . 2815–22 . Nov 1998 . 9763566 . 10.1182/blood.V92.8.2815.
2. Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M . Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64) . Genomics . 38 . 3 . 299–304 . Mar 1997 . 8975706 . 10.1006/geno.1996.0632 .
3. Web site: Entrez Gene: CD180 CD180 molecule.
4. Porakishvili. Nino. Memon. Azka. Vispute. Ketki. Kulikova. Nina. Clark. Edward A.. Rai. Kanti R.. Nathwani. Amit. Damle. Rajendra N.. Chiorazzi. Nicholas. Lydyard. Peter M.. May 2011. CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells. British Journal of Haematology. en. 153. 4. 486–498. 10.1111/j.1365-2141.2011.08605.x. 21443749. 13360804. 0007-1048. free.
5. Gordiienko. Inna. Shlapatska. Larysa. Kholodniuk. Valeriia. Sklyarenko. Lilia. Gluzman. Daniel F.. Clark. Edward A.. Sidorenko. Svetlana P.. 2017-10-05. The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling. PLOS ONE. en. 12. 10. e0185940. 10.1371/journal.pone.0185940. 1932-6203. 5628907. 28982149. 2017PLoSO..1285940G. free.
6. http://www.ominem.org/entry/602226{{Dead link|date=June 2019 |bot=InternetArchiveBot |fix-attempted=yes }} [4<nowiki>]]

   CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.^[3]

   Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.^{[4] [5]}

   Further reading

   • Honda Y, Yamagiwa S, Matsuda Y . Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. . J. Hepatol. . 47 . 3 . 404–11 . 2007 . 17448566 . 10.1016/j.jhep.2007.03.012 . etal.
   • Divanovic S, Trompette A, Atabani SF . Negative Regulation of TLR4 Signaling by RP105 . Nat. Immunol. . 6 . 6 . 571–8 . 2005 . 15852007 . 10.1038/ni1198 . 2144914 . etal.
   • Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
   • Suzuki Y, Yamashita R, Shirota M . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . etal.
   • Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
   • Izmailova E, Bertley FM, Huang Q . HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages . Nat. Med. . 9 . 2 . 191–7 . 2003 . 12539042 . 10.1038/nm822 . 26145639 . etal.
   • Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
   • Miyake K, Shimazu R, Kondo J . Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression . J. Immunol. . 161 . 3 . 1348–53 . 1998 . 10.4049/jimmunol.161.3.1348 . 9686597 . etal.
   • http://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(11)00314-4/fulltext

   External links

   ]