CD177 explained

CD177 antigen is a protein that in humans is encoded by the CD177 gene.^{[1] [2] [3]}

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). [supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• Stroncek D . Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology . Vox Sang. . 83 . 359–61 . 2003 . Suppl 1 . 12617169 . 10.1111/j.1423-0410.2002.tb05334.x. 36683379 .
• Pahl HL . PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera . Curr. Hematol. Rep. . 2 . 3 . 231–6 . 2003 . 12901344 .
• Kralovics R, Skoda RC . Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders . Blood Rev. . 19 . 1 . 1–13 . 2005 . 15572213 . 10.1016/j.blre.2004.02.002 .
• Goldschmeding R . Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils . Br. J. Haematol. . 81 . 3 . 336–45 . 1992 . 1382544 . 10.1111/j.1365-2141.1992.tb08237.x . van Dalen CM . Faber N . 3 . Calafat . J. . Huizinga . T. W. J. . Schoot . C. E. . Clement . L. T. . Borne . A. E. G. Kr. . 11604830 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Stroncek DF, Herr GP, Plachta LB . Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions . J. Lab. Clin. Med. . 123 . 2 . 247–55 . 1994 . 8301201 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Kissel K . Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions . Eur. J. Immunol. . 31 . 5 . 1301–9 . 2001 . 11465086 . 10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J . Santoso S . Hofmann C . 3 . Stroncek . David . Bux . Jürgen . 33769082 . free .
• Bettinotti MP, Olsen A, Stroncek D . The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177 . Clin. Immunol. . 102 . 2 . 138–44 . 2002 . 11846455 . 10.1006/clim.2001.5154 .
• Kissel K, Scheffler S, Kerowgan M, Bux J . Molecular basis of NB1 (HNA-2a, CD177) deficiency . Blood . 99 . 11 . 4231–3 . 2002 . 12010833 . 10.1182/blood.V99.11.4231 . free .
• Klippel S . Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera . Blood . 100 . 7 . 2441–8 . 2002 . 12239154 . 10.1182/blood-2002-03-0949 . Strunck E . Busse CE . 3 . Behringer . D . Pahl . HL . free .
• Teofili L . Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia . J. Clin. Oncol. . 20 . 20 . 4249–54 . 2002 . 12377969 . 10.1200/JCO.2002.11.507 . Martini M . Luongo M . 3 . Di Mario . A . Leone . G . De Stefano . V . Larocca . LM .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Najfeld V . Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis . Exp. Hematol. . 31 . 2 . 118–21 . 2003 . 12591276 . 10.1016/S0301-472X(02)01032-9 . Fuchs S . Merando P . 3 . Lezon-Geyda . Kimberly . Fruchtman . Steven . free.
• Wolff J . Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms . Blood . 102 . 2 . 731–3 . 2003 . 12623849 . 10.1182/blood-2002-09-2831 . Brendel C . Fink L . 3 . Bohle . RM . Kissel . K . Bux . J . free.
• Johansson P . The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia . Eur. J. Haematol. . 70 . 6 . 358–62 . 2003 . 12756017 . 10.1034/j.1600-0609.2003.00079.x . Andréasson B . Safai-Kutti S . 3 . Wennström . Lovisa . Palmqvist . Lars . Ricksten . Anne . Lindstedt . Göran . Kutti . Jack . 13222207 .

Notes and References

1. Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL . Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera . Blood . 95 . 8 . 2569–76 . May 2000 . 10753836 . 10.1182/blood.V95.8.2569.
2. Lalezari P, Murphy GB, ((Allen FH Jr)) . NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia . J Clin Invest . 50 . 5 . 1108–15 . Jun 1971 . 5552408 . 292033 . 10.1172/JCI106582 .
3. Web site: Entrez Gene: CD177 CD177 molecule.