CD164 explained

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.^[1] CD164 functions as a cell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.^[2]

Further reading

• Zannettino AC . CD164. . J. Biol. Regul. Homeost. Agents . 15 . 4 . 394–6 . 2001. 11862985 .
• Masuzawa Y, Miyauchi T, Hamanoue M . A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. . J. Biochem. . 112 . 5 . 609–15 . 1992 . 1478919 . 10.1093/oxfordjournals.jbchem.a123948. etal.
• Zhou GQ, Zhang Y, Ferguson DJ . The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation. . J. Cell. Biochem. . 99 . 5 . 1380–96 . 2006 . 16924678 . 10.1002/jcb.20965 . 6995864 . etal.
• Chan JY, Lee-Prudhoe JE, Jorgensen B . Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. . J. Biol. Chem. . 276 . 3 . 2139–52 . 2001 . 11027692 . 10.1074/jbc.M007965200 . etal. free .
• Ganesh SK, Zakai NA, van Rooij FJ . Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium . Nat. Genet. . 41 . 11 . 1191–8 . 2009 . 19862010 . 2778265 . 10.1038/ng.466 . etal.
• Barbe L, Lundberg E, Oksvold P . Toward a confocal subcellular atlas of the human proteome . Mol. Cell. Proteomics . 7 . 3 . 499–508 . 2008 . 18029348 . 10.1074/mcp.M700325-MCP200 . etal. free .
• Kurosawa N, Kanemitsu Y, Matsui T . Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164 . Eur. J. Biochem. . 265 . 1 . 466–72 . 1999 . 10491205 . 10.1046/j.1432-1327.1999.00777.x . etal.
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Doyonnas R, Yi-Hsin Chan J, Butler LH . CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor . J. Immunol. . 165 . 2 . 840–51 . 2000 . 10878358 . 10.4049/jimmunol.165.2.840. etal. free .
• Gudbjartsson DF, Walters GB, Thorleifsson G . Many sequence variants affecting diversity of adult human height . Nat. Genet. . 40 . 5 . 609–15 . 2008 . 18391951 . 10.1038/ng.122 . 3005450 . etal.
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
• Havens AM, Jung Y, Sun YX . The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis . BMC Cancer . 6. 195 . 2006 . 16859559 . 1557671 . 10.1186/1471-2407-6-195 . etal . free .
• Forde S, Tye BJ, Newey SE . Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells . Blood . 109 . 5 . 1825–33 . 2007 . 17077324 . 10.1182/blood-2006-05-023028 . 14472393 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Hennersdorf F, Florian S, Jakob A . Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation . Cell Res. . 15 . 5 . 325–35 . 2005 . 15916720 . 10.1038/sj.cr.7290301 . etal. free .

Notes and References

1. Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ . The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis . Blood . 92 . 8 . 2613–28 . October 1998 . 9763543 . 10.1182/blood.V92.8.2613.
2. Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH . CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21 . Blood . 92 . 3 . 849–66 . August 1998 . 9680353 . 10.1182/blood.V92.3.849.