Interleukin-9 receptor explained

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.^[1]

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

Interactions

Interleukin-9 receptor has been shown to interact with YWHAZ.^[2]

See also

• Cluster of differentiation

Further reading

• Knoops L, Renauld JC . IL-9 and its receptor: from signal transduction to tumorigenesis . Growth Factors . 22 . 4 . 207–15 . 2005 . 15621723 . 10.1080/08977190410001720879 . 40523692 .
• Renauld JC, Druez C, Kermouni A, etal . Expression cloning of the murine and human interleukin 9 receptor cDNAs . Proc. Natl. Acad. Sci. U.S.A. . 89 . 12 . 5690–4 . 1992 . 1376929 . 10.1073/pnas.89.12.5690 . 49358 . 1992PNAS...89.5690R . free .
• Kimura Y, Takeshita T, Kondo M, etal . Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex . Int. Immunol. . 7 . 1 . 115–20 . 1995 . 7718508 . 10.1093/intimm/7.1.115 .
• Chang MS, Engel G, Benedict C, etal . Isolation and characterization of the human interleukin-9 receptor gene . Blood . 83 . 11 . 3199–205 . 1994 . 10.1182/blood.V83.11.3199.3199 . 8193355 . free .
• Kermouni A, Van Roost E, Arden KC, etal . The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter . Genomics . 29 . 2 . 371–82 . 1996 . 8666384 . 10.1006/geno.1995.9992 .
• Demoulin JB, Uyttenhove C, Van Roost E, etal . A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 . Mol. Cell. Biol. . 16 . 9 . 4710–6 . 1996 . 8756628 . 10.1128/MCB.16.9.4710. 231471.
• Vermeesch JR, Petit P, Kermouni A, etal . The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y . Hum. Mol. Genet. . 6 . 1 . 1–8 . 1997 . 9002663 . 10.1093/hmg/6.1.1 . free .
• Bauer JH, Liu KD, You Y, etal . Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis . J. Biol. Chem. . 273 . 15 . 9255–60 . 1998 . 9535918 . 10.1074/jbc.273.15.9255 . free .
• Levitt RC, McLane MP, MacDonald D, etal . IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders . J. Allergy Clin. Immunol. . 103 . 5 Pt 2 . S485–91 . 1999 . 10329852 . 10.1016/S0091-6749(99)70165-X .
• Sliva D, Zhu YX, Tsai S, etal . Tip60 interacts with human interleukin-9 receptor alpha-chain . Biochem. Biophys. Res. Commun. . 263 . 1 . 149–55 . 1999 . 10486269 . 10.1006/bbrc.1999.1083 .
• Sliva D, Gu M, Zhu YX, etal . 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor . Biochem. J. . 345 . 3. 741–7 . 2000 . 10642536 . 10.1042/0264-6021:3450741 . 1220812 .
• Ciccodicola A, D'Esposito M, Esposito T, etal . Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region . Hum. Mol. Genet. . 9 . 3 . 395–401 . 2000 . 10655549 . 10.1093/hmg/9.3.395 . free .
• De Smedt M, Verhasselt B, Kerre T, etal . Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development . J. Immunol. . 164 . 4 . 1761–7 . 2000 . 10657622 . 10.4049/jimmunol.164.4.1761. free .
• Kauppi P, Laitinen T, Ollikainen V, etal . The IL9R region contribution in asthma is supported by genetic association in an isolated population . Eur. J. Hum. Genet. . 8 . 10 . 788–92 . 2001 . 11039580 . 10.1038/sj.ejhg.5200541 . free .
• Abdelilah S, Latifa K, Esra N, etal . Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release . J. Immunol. . 166 . 4 . 2768–74 . 2001 . 11160343 . 10.4049/jimmunol.166.4.2768. free .
• Asao H, Okuyama C, Kumaki S, etal . Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex . J. Immunol. . 167 . 1 . 1–5 . 2001 . 11418623 . 10.4049/jimmunol.167.1.1. free .
• Little FF, Cruikshank WW, Center DM . Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells . Am. J. Respir. Cell Mol. Biol. . 25 . 3 . 347–52 . 2001 . 11588013 . 10.1165/ajrcmb.25.3.4349.
• Tsukadaira A, Okubo Y, Koyama S, etal . Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor . Exp. Lung Res. . 28 . 2 . 123–39 . 2002 . 11868823 . 10.1080/019021402753462040 . 26893804 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Melén E, Gullstén H, Zucchelli M, etal . Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation . J. Med. Genet. . 41 . 12 . e123 . 2005 . 15591265 . 10.1136/jmg.2004.023135 . 1735647 .

Notes and References

1. Web site: Entrez Gene: IL9R interleukin 9 receptor.
2. Sliva . D . Gu M . Zhu Y X . Chen J . Tsai S . Du X . Yang Y C . February 2000 . 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor . Biochem. J. . 345 . 3. 741–7 . 0264-6021. 10642536 . 1220812 . 10.1042/0264-6021:3450741.