CD120 explained

tumor necrosis factor receptor superfamily, member 1A
Hgncid:	11916
Symbol:	TNFRSF1A
Altsymbols:	CD120a, TNFR1
Entrezgene:	7132
Omim:	191190
Refseq:	NM_001065
Uniprot:	P19438
Chromosome:	12
Arm:	p
Band:	13.2

tumor necrosis factor receptor superfamily, member 1B
Hgncid:	11917
Symbol:	TNFRSF1B
Altsymbols:	CD120a, TNFR2
Entrezgene:	7133
Omim:	191191
Refseq:	NM_001066
Uniprot:	P20333
Chromosome:	1
Arm:	p
Band:	36.22

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).^{[1] [2]}

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

• CD120a - TNFR1 - TNFR superfamily member 1A
• CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,^[3] and is involved in neurotoxic processes.^[4] Elevated levels of TNFR1 has been found in severe mental disorders.^[5]

Signaling pathway

See also

• Cluster of differentiation

Notes and References

1. Locksley RM, Killeen N, Lenardo MJ . The TNF and TNF receptor superfamilies: integrating mammalian biology . Cell . 104 . 4 . 487–501 . 2001 . 11239407 . 10.1016/S0092-8674(01)00237-9 . 7657797 . free .
2. Hehlgans T, Pfeffer K . The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games . Immunology . 115 . 1 . 1–20 . 2005 . 15819693 . 10.1111/j.1365-2567.2005.02143.x . 1782125 .
3. Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW . The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior . Psychopharmacology . 201 . 4 . 549–56 . January 2009 . 18825372 . 2711641 . 10.1007/s00213-008-1331-4 .
4. McCoy MK, Tansey MG . TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease . J Neuroinflammation . 5 . 1. 45 . 2008 . 18925972 . 2577641 . 10.1186/1742-2094-5-45 . free .
5. Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA . Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor . Bipolar Disord . 11 . 7 . 726–34 . November 2009 . 19839997 . 10.1111/j.1399-5618.2009.00757.x . 10852/34620 . free .