CD109 explained

CD109 (Cluster of Differentiation 109) is a human gene.

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15),^[1] implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]^[2]

See also

• Cluster of differentiation

Further reading

• Lucas GF, Metcalfe P . Platelet and granulocyte glycoprotein polymorphisms. . Transfusion Medicine (Oxford, England) . 10 . 3 . 157–74 . 2000 . 10972910 . 10.1046/j.1365-3148.2000.00250.x. 43709043 .
• Sutherland DR, Yeo E, Ryan A . Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets. . Blood . 77 . 1 . 84–93 . 1991 . 1984805 . 10.1182/blood.V77.1.84.84. etal. free .
• Kelton JG, Smith JW, Horsewood P . Gova/b alloantigen system on human platelets. . Blood . 75 . 11 . 2172–6 . 1990 . 2346781 . 10.1182/blood.V75.11.2172.2172. etal. free .
• Lin M, Sutherland DR, Horsfall W . Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. . Blood . 99 . 5 . 1683–91 . 2002 . 11861284 . 10.1182/blood.V99.5.1683 . etal. free .
• Schuh AC, Watkins NA, Nguyen Q . A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. . Blood . 99 . 5 . 1692–8 . 2002 . 11861285 . 10.1182/blood.V99.5.1692 . etal. free .
• Giesert C, Marxer A, Sutherland DR . Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets. . Ann. N. Y. Acad. Sci. . 996 . 227–30 . 2003 . 1 . 12799300 . 10.1111/j.1749-6632.2003.tb03250.x . 2003NYASA.996..227G . 24117857 . etal.
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Solomon KR, Sharma P, Chan M . CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family. . Gene . 327 . 2 . 171–83 . 2004 . 14980714 . 10.1016/j.gene.2003.11.025 . etal. free .
• Zhang JM, Hashimoto M, Kawai K . CD109 expression in squamous cell carcinoma of the uterine cervix. . Pathol. Int. . 55 . 4 . 165–9 . 2005 . 15826242 . 10.1111/j.1440-1827.2005.01807.x . 24693926 . etal.
• Lewandrowski U, Moebius J, Walter U, Sickmann A . Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. . Mol. Cell. Proteomics . 5 . 2 . 226–33 . 2006 . 16263699 . 10.1074/mcp.M500324-MCP200 . free .
• Liu T, Qian WJ, Gritsenko MA . Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . etal.
• Finnson KW, Tam BY, Liu K . Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes . FASEB J. . 20 . 9 . 1525–7 . 2006 . 16754747 . 10.1096/fj.05-5229fje . free . 30768709 . etal.
• Sjöblom T, Jones S, Wood LD . The consensus coding sequences of human breast and colorectal cancers . Science . 314 . 5797 . 268–74 . 2006 . 16959974 . 10.1126/science.1133427 . 2006Sci...314..268S . 10805017 . etal.
• Hasegawa M, Hagiwara S, Sato T . CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells . Pathol. Int. . 57 . 5 . 245–50 . 2007 . 17493171 . 10.1111/j.1440-1827.2007.02097.x . 23930267 . etal.

Notes and References

1. Web site: IPD - HPA Sequence Database| EBI.
2. Web site: Entrez Gene: CD109 CD109 molecule.