CCT7 explained

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.^{[1] [2]}

Function

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.

Interactions

CCT7 has been shown to interact with PPP4C.^{[3] [4]}

References

Further reading

• Kubota H, Hynes G, Carne A, Ashworth A, Willison K. Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Current Biology. 4. 2. 89–99. Feb 1994. 7953530. 10.1016/S0960-9822(94)00024-2. 1994CBio....4...89K . 31300131.
• Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138. 1–2. 171–4. Jan 1994. 8125298. 10.1016/0378-1119(94)90802-8.
• Hynes G, Celis JE, Lewis VA, Carne A, U S, Lauridsen JB, Willison KR. Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits. Electrophoresis. 17. 11. 1720–7. 1996. Nov 1996. 8982604. 10.1002/elps.1150171109. 11257092.
• Liou AK, Willison KR. Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. The EMBO Journal. 16. 14. 4311–6. Jul 1997. 9250675. 1170057. 10.1093/emboj/16.14.4311.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 200. 1–2. 149–56. Oct 1997. 9373149. 10.1016/S0378-1119(97)00411-3.
• Yokota S, Yanagi H, Yura T, Kubota H. Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. European Journal of Biochemistry. 268. 17. 4664–73. Sep 2001. 11532003. 10.1046/j.1432-1327.2001.02393.x.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y. Protein-protein interaction panel using mouse full-length cDNAs. Genome Research. 11. 10. 1758–65. Oct 2001. 11591653. 311163. 10.1101/gr.180101.
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. The Journal of Biological Chemistry. 278. 51. 51901–10. 2003. Dec 2003. 14532270. 10.1074/jbc.M309655200. free.
• Hanafy KA, Martin E, Murad F. CCTeta, a novel soluble guanylyl cyclase-interacting protein. The Journal of Biological Chemistry. 279. 45. 46946–53. Nov 2004. 15347653. 10.1074/jbc.M404134200. free.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122. 6. 957–68. Sep 2005. 16169070. 10.1016/j.cell.2005.08.029. 11858/00-001M-0000-0010-8592-0. 8235923. free.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Biochemical and Biophysical Research Communications. 337. 4. 1308–18. Dec 2005. 16236267. 10.1016/j.bbrc.2005.09.191.

Notes and References

1. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI . Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT . Molecular and Cellular Biology . 18 . 12 . 7584–9 . Dec 1998 . 9819444 . 109339 . 10.1128/mcb.18.12.7584.
2. Web site: Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta).
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC . PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 . The Journal of Biological Chemistry . 283 . 43 . 29273–84 . Oct 2008 . 18715871 . 2662017 . 10.1074/jbc.M803443200 . free .
4. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R . A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity . Molecular & Cellular Proteomics . 4 . 11 . 1725–40 . Nov 2005 . 16085932 . 10.1074/mcp.M500231-MCP200 . free .