CCT6A explained

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.^{[1] [2] [3]}

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Interactions

CCT6A has been shown to interact with PPP4C.^{[4] [5]}

References

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Kubota H, Hynes G, Carne A, Ashworth A, Willison K . Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin . Curr. Biol. . 4 . 2 . 89–99 . 1994 . 7953530 . 10.1016/S0960-9822(94)00024-2 . 1994CBio....4...89K . 31300131 .
• Schwartz GJ, Kittelberger AM, Segel GB . Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues . Exp. Nephrol. . 8 . 3 . 152–60 . 2000 . 10810232 . 10.1159/000020663 . 28781053 .
• Yokota S, Yanagi H, Yura T, Kubota H . Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle . Eur. J. Biochem. . 268 . 17 . 4664–73 . 2001 . 11532003 . 10.1046/j.1432-1327.2001.02393.x .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R . A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death . J. Biol. Chem. . 278 . 51 . 51901–10 . 2004 . 14532270 . 10.1074/jbc.M309655200 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, Seki N, Tanzawa H . Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays . Oncol. Rep. . 14 . 5 . 1293–8 . 2005 . 16211299 . 10.3892/or.14.5.1293 .
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY . Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress . Biochem. Biophys. Res. Commun. . 337 . 4 . 1308–18 . 2005 . 16236267 . 10.1016/j.bbrc.2005.09.191 .

Notes and References

1. Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F . Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA . Proc Natl Acad Sci U S A . 89 . 13 . 6060–4 . August 1992 . 1352881 . 49437 . 10.1073/pnas.89.13.6060 . free . 1992PNAS...89.6060S .
2. Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F . Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast . J Biol Chem . 269 . 28 . 18616–22 . August 1994 . 10.1016/S0021-9258(17)32354-2 . 8034610 . free .
3. Web site: Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1).
4. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC . PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4 . J. Biol. Chem. . 283 . 43 . 29273–84 . October 2008 . 18715871 . 2662017 . 10.1074/jbc.M803443200 . free .
5. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R . A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity . Mol. Cell. Proteomics . 4 . 11 . 1725–40 . November 2005 . 16085932 . 10.1074/mcp.M500231-MCP200 . free .