CCT4 explained

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene.^{[1] [2]} The CCT4 protein is a component of the TRiC complex.

Interactions

CCT4 has been shown to interact with PPP4C.^{[3] [4]}

Further reading

• Kubota H, Hynes G, Carne A, Ashworth A, Willison K . Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin . Current Biology . 4 . 2 . 89–99 . Feb 1994 . 7953530 . 10.1016/S0960-9822(94)00024-2 . 1994CBio....4...89K . 31300131 .
• Richard Gaynor. Wu-Baer F, Lane WS, Gaynor RB . Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA . The Journal of Biological Chemistry . 271 . 8 . 4201–8 . Feb 1996 . 8626763 . 10.1074/jbc.271.8.4201 . free .
• Nabetani A, Hatada I, Morisaki H, Mukai T . Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11 . Genomics . 34 . 2 . 246–9 . June 1996 . 8661059 . 10.1006/geno.1996.0276 .
• Melki R, Batelier G, Soulié S, Williams RC . Cytoplasmic chaperonin containing TCP-1: structural and functional characterization . Biochemistry . 36 . 19 . 5817–26 . May 1997 . 9153422 . 10.1021/bi962830o .
• Llorca O, McCormack EA, Hynes G, Grantham J, Cordell J, Carrascosa JL, Willison KR, Fernandez JJ, Valpuesta JM . Eukaryotic type II chaperonin CCT interacts with actin through specific subunits . Nature . 402 . 6762 . 693–6 . December 1999 . 10604479 . 10.1038/45294 . 1999Natur.402..693L . 4421057 .
• Llorca O, Martín-Benito J, Gómez-Puertas P, Ritco-Vonsovici M, Willison KR, Carrascosa JL, Valpuesta JM . Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin . Journal of Structural Biology . 135 . 2 . 205–18 . August 2001 . 11580270 . 10.1006/jsbi.2001.4359 .
• Parissi V, Calmels C, De Soultrait VR, Caumont A, Fournier M, Chaignepain S, Litvak S . Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60 . Journal of Virology . 75 . 23 . 11344–53 . Dec 2001 . 11689615 . 114720 . 10.1128/JVI.75.23.11344-11353.2001 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R . A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death . The Journal of Biological Chemistry . 278 . 51 . 51901–10 . December 2003 . 14532270 . 10.1074/jbc.M309655200 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . Journal of Proteome Research . 5 . 11 . 3135–44 . November 2006 . 17081065 . 10.1021/pr060363j .

Notes and References

1. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI . Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT . Molecular and Cellular Biology . 18 . 12 . 7584–9 . Dec 1998 . 9819444 . 109339 . 10.1128/mcb.18.12.7584.
2. Web site: Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta).
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC . PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 . The Journal of Biological Chemistry . 283 . 43 . 29273–84 . Oct 2008 . 18715871 . 2662017 . 10.1074/jbc.M803443200 . free .
4. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R . A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity . Molecular & Cellular Proteomics . 4 . 11 . 1725–40 . November 2005 . 16085932 . 10.1074/mcp.M500231-MCP200 . 7531012 . free .