CCT3 explained

T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.^{[1] [2]}

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

CCT3 has been shown to interact with PPP4C.^{[3] [4]}

Further reading

• Kubota H, Hynes G, Carne A, Ashworth A, Willison K . Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin . Current Biology . 4 . 2 . 89–99 . Feb 1994 . 7953530 . 10.1016/S0960-9822(94)00024-2 . 1994CBio....4...89K . 31300131 .
• Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N . Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization . Genomics . 22 . 3 . 634–6 . Aug 1994 . 8001976 . 10.1006/geno.1994.1438 .
• Walkley NA, Demaine AG, Malik AN . Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma . The Biochemical Journal . 313 . Pt 2 . 381–9 . Jan 1996 . 8573069 . 1216920 . 10.1042/bj3130381.
• Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J . Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC . Molecular Cell . 4 . 6 . 1051–61 . Dec 1999 . 10635329 . 10.1016/S1097-2765(00)80233-6 . free .
• Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ . Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression . Journal of Hepatology . 38 . 3 . 298–306 . Mar 2003 . 12586295 . 10.1016/S0168-8278(02)00412-9 .
• Yuryev A, Wennogle LP . Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis . Genomics . 81 . 2 . 112–25 . Feb 2003 . 12620389 . 10.1016/S0888-7543(02)00008-3 .
• Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport . Experimental Cell Research . 289 . 2 . 211–21 . Oct 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 .
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R . A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death . The Journal of Biological Chemistry . 278 . 51 . 51901–10 . Dec 2003 . 14532270 . 10.1074/jbc.M309655200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V . cDNA encoding a novel TCP1-related protein . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1217 . 2 . 224–6 . Mar 1994 . 8110840 . 10.1016/0167-4781(94)90041-8 .
2. Web site: Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma).
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC . PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 . The Journal of Biological Chemistry . 283 . 43 . 29273–84 . Oct 2008 . 18715871 . 2662017 . 10.1074/jbc.M803443200 . free .
4. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R . A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity . Molecular & Cellular Proteomics . 4 . 11 . 1725–40 . Nov 2005 . 16085932 . 10.1074/mcp.M500231-MCP200 . free .