CCRL2 explained

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.^{[1] [2]} Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.^[3]

Function

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.^[2]

Further reading

• Daugherty BL, Springer MS . The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. . Genomics . 41 . 2 . 294–5 . 1997 . 9143512 . 10.1006/geno.1997.4626 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Galligan CL . Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis . Arthritis Rheum. . 50 . 6 . 1806–14 . 2004 . 15188357 . 10.1002/art.20275 . vanc. Matsuyama W . Matsukawa A . 3 . Mizuta . Hiroshi . Hodge . David R. . Howard . O. M. Zack . Yoshimura . Teizo .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Muzny DM . The DNA sequence, annotation and analysis of human chromosome 3 . Nature . 440 . 7088 . 1194–8 . 2006 . 16641997 . 10.1038/nature04728 . vanc. Scherer SE . Kaul R . 3 . Wang . Jing . Yu . Jun . Sudbrak . Ralf . Buhay . Christian J. . Chen . Rui . Cree . Andrew . 2006Natur.440.1194M . free .

Notes and References

1. Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y . Cloning and characterization of a novel human chemokine receptor . Biochem Biophys Res Commun . 243 . 1 . 264–8 . Mar 1998 . 9473515 . 10.1006/bbrc.1997.7981 .
2. Web site: Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2.
3. Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC . Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis . J. Exp. Med. . 205 . 10 . 2207–20 . September 2008 . 18794339 . 2556791 . 10.1084/jem.20080300 .