CCRL1 explained

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.^[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.^[2]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Bacon KB, Schall TJ, Dairaghi DJ . RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA . J. Immunol. . 160 . 4 . 1894–900 . 1998 . 10.4049/jimmunol.160.4.1894 . 9469451 . free .
• Gosling J, Dairaghi DJ, Wang Y . Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK . J. Immunol. . 164 . 6 . 2851–6 . 2000 . 10706668 . 10.4049/jimmunol.164.6.2851. etal. free .
• Schweickart VL, Epp A, Raport CJ, Gray PW . CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines . J. Biol. Chem. . 275 . 13 . 9550–6 . 2000 . 10734104 . 10.1074/jbc.275.13.9550 . free .
• Schweickart VL, Epp A, Raport CJ, Gray PW . CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines . The Journal of Biological Chemistry. 276 . 1 . 856 . 2001. 11134065 .
• Townson JR, Nibbs RJ . Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR . Eur. J. Immunol. . 32 . 5 . 1230–41 . 2002 . 11981810 . 10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. 21911348 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Comerford I, Milasta S, Morrow V . The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro . Eur. J. Immunol. . 36 . 7 . 1904–16 . 2006 . 16791897 . 10.1002/eji.200535716 . 31855788 . etal.

Notes and References

1. Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V . Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart . Gene . 246 . 1–2 . 229–38 . May 2000 . 10767544 . 10.1016/S0378-1119(00)00076-7 .
2. Web site: Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1.