CCR10 explained

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.^{[1] [2]}

Function

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.^[3] This receptor is normally expressed by melanocytes,^[4] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,^[5] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.^[6]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Bonini JA . Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3 . DNA Cell Biol. . 16 . 10 . 1249–56 . 1997 . 9364936 . 10.1089/dna.1997.16.1249 . Martin SK . Dralyuk F . 3 . Roe . Michael W. . Philipson . Louis H. . Steiner . Donald F. .
• Gosling J . Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK . J. Immunol. . 164 . 6 . 2851–6 . 2000 . 10706668 . 10.4049/jimmunol.164.6.2851. Dairaghi DJ . Wang Y . 3 . Hanley . M . Talbot . D . Miao . Z . Schall . TJ . free .
• Jarmin DI . Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine . J. Immunol. . 164 . 7 . 3460–4 . 2000 . 10725696 . 10.4049/jimmunol.164.7.3460. Rits M . Bota D . 3 . Gerard . NP . Graham . GJ . Clark-Lewis . I . Gerard . C . free .
• Homey B . Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) . J. Immunol. . 164 . 7 . 3465–70 . 2000 . 10725697 . 10.4049/jimmunol.164.7.3465. Wang W . Soto H . 3 . Buchanan . ME . Wiesenborn . A . Catron . D . Müller . A . McClanahan . TK . Dieu-Nosjean . MC . free .
• Wang W . Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2) . J. Biol. Chem. . 275 . 29 . 22313–23 . 2000 . 10781587 . 10.1074/jbc.M001461200 . Soto H . Oldham ER . 3 . Buchanan . ME . Homey . B . Catron . D . Jenkins . N . Copeland . NG . Gilbert . DJ . free .
• Pan J . A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues . J. Immunol. . 165 . 6 . 2943–9 . 2000 . 10975800 . 10.4049/jimmunol.165.6.2943. Kunkel EJ . Gosslar U . 3 . Lazarus . N . Langdon . P . Broadwell . K . Vierra . MA . Genovese . MC . Butcher . EC . free .
• Patel L, Charlton SJ, Chambers JK, Macphee CH . Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations . Cytokine . 14 . 1 . 27–36 . 2001 . 11298490 . 10.1006/cyto.2000.0851 .
• Homey B . CCL27-CCR10 interactions regulate T cell-mediated skin inflammation . Nat. Med. . 8 . 2 . 157–65 . 2002 . 11821900 . 10.1038/nm0202-157 . Alenius H . Müller A . 3 . Soto . Hortensia . Bowman . Edward P. . Yuan . Wei . McEvoy . Leslie . Lauerma . Antti I. . Assmann . Till . 35433583 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Lehner B . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . Semple JI . Brown SE . 3 . Counsell . Damian . Campbell . R.Duncan . Sanderson . Christopher M .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Notohamiprodjo M . CCR10 is expressed in cutaneous T-cell lymphoma . Int. J. Cancer . 115 . 4 . 641–7 . 2005 . 15700309 . 10.1002/ijc.20922 . Segerer S . Huss R . 3 . Hildebrandt . Bernhard . Soler . Dulce . Djafarzadeh . Roghieh . Buck . Wiebke . Nelson . Peter J. . Von Luettichau . Irene . 45425929 . free .
• Rodrigues-Lisoni FC . In vitro and in vivo studies on CCR10 regulation by Annexin A1 . FEBS Lett. . 580 . 5 . 1431–8 . 2006 . 16460738 . 10.1016/j.febslet.2006.01.072 . Mehet DK . Mehemet DK . 3 . John . C . Tajara . E . Buckingham . J . Solito . E . Solito . E . 11449/21716 . 11454792 . free .
• Fujita Y . Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides . Clin. Cancer Res. . 12 . 9 . 2670–5 . 2006 . 16675558 . 10.1158/1078-0432.CCR-05-1513 . Abe R . Sasaki M . 3 . Honda . A . Furuichi . M . Asano . Y . Norisugi . O . Shimizu . T . Shimizu . H . 6562342 .
• Eksteen B . Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10 . J. Immunol. . 177 . 1 . 593–603 . 2006 . 16785557 . 10.4049/jimmunol.177.1.593. Miles A . Curbishley SM . 3 . Tselepis . C . Grant . AJ . Walker . LS . Adams . DH . 43279609 .
• Harasawa H . Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma . Leuk. Lymphoma . 47 . 10 . 2163–73 . 2007 . 17071491 . 10.1080/10428190600775599 . Yamada Y . Hieshima K . 3 . Jin . Zhe . Nakayama . Takashi . Yoshie . Osamu . Shimizu . Kazuhiro . Hasegawa . Hiroo . Hayashi . Tomayoshi . 32495340 .

External links

• • Web site: Chemokine Receptors: CCR10 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Notes and References

1. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF . Cloning of human genes encoding novel G protein-coupled receptors . Genomics . 23 . 3 . 609–18 . Mar 1995 . 7851889 . 10.1006/geno.1994.1549 .
2. Web site: Entrez Gene: CCR10 chemokine (C-C motif) receptor 10.
3. Balkwill F . Cancer and the chemokine network . Nat. Rev. Cancer . 4 . 7 . 540–50 . July 2004 . 15229479 . 10.1038/nrc1388 . 205467365 .
4. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A . Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) . J. Immunol. . 164 . 7 . 3465–70 . April 2000 . 10725697 . 10.4049/jimmunol.164.7.3465. free .
5. Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST . Immune evasion by murine melanoma mediated through CC chemokine receptor-10 . J. Exp. Med. . 198 . 9 . 1337–47 . November 2003 . 14581607 . 2194242 . 10.1084/jem.20030593 .
6. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A . CCL27-CCR10 interactions regulate T cell-mediated skin inflammation . Nat. Med. . 8 . 2 . 157–65 . February 2002 . 11821900 . 10.1038/nm0202-157 . 35433583 .