CCR1 explained

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[1]

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

Function

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.^[2]

Interactions

CCR1 has been shown to interact with CCL5.^{[3] [4]}

Further reading

• Gerard C, Gerard NP . C5A anaphylatoxin and its seven transmembrane-segment receptor . Annual Review of Immunology . 12 . 1 . 775–808 . 1994 . 8011297 . 10.1146/annurev.iy.12.040194.004015 .
• Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM . HIV-1 infection and chemokine receptor modulation . Current HIV Research . 2 . 1 . 39–50 . January 2004 . 15053339 . 10.2174/1570162043484997 .
• Nomura H, Nielsen BW, Matsushima K . Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors . . 5 . 10 . 1239–49 . October 1993 . 7505609 . 10.1093/intimm/5.10.1239 .
• Ben-Baruch A, Xu L, Young PR, Bengali K, Oppenheim JJ, Wang JM . Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3 . The Journal of Biological Chemistry . 270 . 38 . 22123–8 . September 1995 . 7545673 . 10.1074/jbc.270.38.22123 . free .
• Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C . Molecular characterization of two murine eosinophil beta chemokine receptors . Journal of Immunology . 155 . 11 . 5299–305 . December 1995 . 10.4049/jimmunol.155.11.5299 . 7594543 . 12074627 .
• Gao JL, Kuhns DB, Tiffany HL, McDermott D, Li X, Francke U, Murphy PM . Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor . The Journal of Experimental Medicine . 177 . 5 . 1421–7 . May 1993 . 7683036 . 2191019 . 10.1084/jem.177.5.1421 .
• Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM . Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B . The Journal of Biological Chemistry . 270 . 50 . 29671–5 . December 1995 . 8530354 . 10.1074/jbc.270.50.29671 . free .
• Kuang Y, Wu Y, Jiang H, Wu D . Selective G protein coupling by C-C chemokine receptors . The Journal of Biological Chemistry . 271 . 8 . 3975–8 . February 1996 . 8626727 . 10.1074/jbc.271.8.3975 . free .
• Boring L, Gosling J, Monteclaro FS, Lusis AJ, Tsou CL, Charo IF . Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9 . The Journal of Biological Chemistry . 271 . 13 . 7551–8 . March 1996 . 8631787 . 10.1074/jbc.271.13.7551 . free .
• Gong X, Gong W, Kuhns DB, Ben-Baruch A, Howard OM, Wang JM . Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors . The Journal of Biological Chemistry . 272 . 18 . 11682–5 . May 1997 . 9115216 . 10.1074/jbc.272.18.11682 . free .
• Daugherty BL, Springer MS . The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21 . Genomics . 41 . 2 . 294–5 . April 1997 . 9143512 . 10.1006/geno.1997.4626 .
• Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hébert CA . Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5 . Biochemistry . 36 . 32 . 9642–8 . August 1997 . 9289016 . 10.1021/bi970593z .
• Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN . Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines . European Journal of Biochemistry . 248 . 2 . 507–15 . September 1997 . 9346309 . 10.1111/j.1432-1033.1997.00507.x . free .
• Youn BS, Zhang SM, Broxmeyer HE, Cooper S, Antol K, Fraser M, Kwon BS . Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1 . Blood . 91 . 9 . 3118–26 . May 1998 . 9558365 . 10.1182/blood.V91.9.3118. free .
• Nardelli B, Tiffany HL, Bong GW, Yourey PA, Morahan DK, Li Y, Murphy PM, Alderson RF . Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1 . Journal of Immunology . 162 . 1 . 435–44 . January 1999 . 10.4049/jimmunol.162.1.435 . 9886417 . free .
• Shaw KT, Greig NH . Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection . NeuroReport . 10 . 1 . 53–6 . January 1999 . 10094132 . 10.1097/00001756-199901180-00010 .
• Zhang S, Youn BS, Gao JL, Murphy PM, Kwon BS . Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1 . Journal of Immunology . 162 . 8 . 4938–42 . April 1999 . 10.4049/jimmunol.162.8.4938 . 10202040 . free .
• Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G . Use of chemokine receptors by poxviruses . Science . 286 . 5446 . 1968–71 . December 1999 . 10583963 . 10.1126/science.286.5446.1968 .

External links

• • Web site: Chemokine Receptors: CCR1 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-11-25 . 2008-06-07 . https://web.archive.org/web/20080607150517/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2220 . dead .

Notes and References

1. Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ . Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor . Cell . 72 . 3 . 415–25 . February 1993 . 7679328 . 10.1016/0092-8674(93)90118-A . 38479816 .
2. Web site: Entrez Gene: CCR1 chemokine (C-C motif) receptor 1.
3. Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J . Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils . European Journal of Immunology . 31 . 7 . 2170–8 . July 2001 . 11449371 . 10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D . free .
4. Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN . The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity . The Journal of Biological Chemistry . 276 . 14 . 10620–6 . April 2001 . 11116158 . 10.1074/jbc.M010867200 . free .