CCP110 explained

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication.^{[1] [2]} CP110 suppresses a cilia assembly program.^[3]

Further reading

• Ishikawa K, Nagase T, Nakajima D . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 4 . 5 . 307–13 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . etal. free .
• Loftus BJ, Kim UJ, Sneddon VP . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. . Genomics . 60 . 3 . 295–308 . 1999 . 10493829 . 10.1006/geno.1999.5927 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Andersen JS, Wilkinson CJ, Mayor T . Proteomic characterization of the human centrosome by protein correlation profiling. . Nature . 426 . 6966 . 570–4 . 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Zou C, Li J, Bai Y . Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. . J. Cell Biol. . 171 . 3 . 437–45 . 2006 . 16275750 . 10.1083/jcb.200506185 . 2171251 . etal.
• Tsang WY, Spektor A, Luciano DJ . CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. . Mol. Biol. Cell . 17 . 8 . 3423–34 . 2006 . 16760425 . 10.1091/mbc.E06-04-0371 . 1525247 . etal.
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Pearson CG, Culver BP, Winey M . Centrioles want to move out and make cilia. . Dev. Cell . 13 . 3 . 319–21 . 2007 . 17765674 . 10.1016/j.devcel.2007.08.007 . free .

Notes and References

1. Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD . CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells . Dev. Cell . 3 . 3 . 339–50 . September 2002 . 12361598 . 10.1016/S1534-5807(02)00258-7 . free .
2. Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD . USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110 . Nature . 495 . 7440 . 255–9 . March 2013 . 23486064 . 10.1038/nature11941 . 3815529. 2013Natur.495..255L .
3. Spektor A, Tsang WY, Khoo D, Dynlacht BD . Cep97 and CP110 suppress a cilia assembly program . Cell . 130 . 4 . 678–90 . August 2007 . 17719545 . 10.1016/j.cell.2007.06.027 . 17974875 . free .