Cyclin O Explained

Cyclin-O is a protein that in humans is encoded by the CCNO gene.^[1]

Interactions

Cyclin O has been shown to interact with RPA2^[2] and PCNA.^{[2] [3]}

Further reading

• Caradonna S, Muller-Weeks S . The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity . Current Protein & Peptide Science . 2 . 4 . 335–47 . December 2001 . 12369930 . 10.2174/1389203013381044 .
• Muller SJ, Caradonna S . Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1088 . 2 . 197–207 . February 1991 . 2001396 . 10.1016/0167-4781(91)90055-Q .
• Muller SJ, Caradonna S . Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase . The Journal of Biological Chemistry . 268 . 2 . 1310–9 . January 1993 . 10.1016/S0021-9258(18)54076-X . 8419333 . free .
• Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE . Post-replicative base excision repair in replication foci . The EMBO Journal . 18 . 13 . 3834–44 . July 1999 . 10393198 . 1171460 . 10.1093/emboj/18.13.3834 .
• Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles CJ, Edwards AM, Chazin WJ . Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA . Cell . 103 . 3 . 449–56 . October 2000 . 11081631 . 10.1016/S0092-8674(00)00136-7 . 16640087 . free .
• Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G . hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup . The Journal of Biological Chemistry . 277 . 42 . 39926–36 . October 2002 . 12161446 . 10.1074/jbc.M207107200 . free .
• Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T . A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein . The Journal of Biological Chemistry . 277 . 43 . 40362–7 . October 2002 . 12171929 . 10.1074/jbc.M206194200 . free .
• Priet S, Navarro JM, Gros N, Quérat G, Sire J . Differential incorporation of uracil DNA glycosylase UNG2 into HIV-1, HIV-2, and SIV(MAC) viral particles . Virology . 307 . 2 . 283–9 . March 2003 . 12667798 . 10.1016/S0042-6822(02)00073-9 . free .
• Elder RT, Zhu X, Priet S, Chen M, Yu M, Navarro JM, Sire J, Zhao Y . A fission yeast homologue of the human uracil-DNA-glycosylase and their roles in causing DNA damage after overexpression . Biochemical and Biophysical Research Communications . 306 . 3 . 693–700 . July 2003 . 12810074 . 10.1016/S0006-291X(03)01036-2 .
• Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA . The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair . Molecular Cell . 15 . 4 . 621–34 . August 2004 . 15327777 . 10.1016/j.molcel.2004.08.007 . free .
• Hirst R, Gosden R, Miller D . The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues . Gene . 375 . 95–102 . June 2006 . 16697536 . 10.1016/j.gene.2006.02.030 .
• Verma SC, Bajaj BG, Cai Q, Si H, Seelhammer T, Robertson ES . Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus . Journal of Virology . 80 . 22 . 11178–90 . November 2006 . 16928741 . 1642147 . 10.1128/JVI.01334-06 .
• Yang B, Chen K, Zhang C, Huang S, Zhang H . Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA . The Journal of Biological Chemistry . 282 . 16 . 11667–75 . April 2007 . 17272283 . 10.1074/jbc.M606864200 . free .
• Schröfelbauer B, Hakata Y, Landau NR . HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1 . Proceedings of the National Academy of Sciences of the United States of America . 104 . 10 . 4130–5 . March 2007 . 17360488 . 1820720 . 10.1073/pnas.0610167104 . 2007PNAS..104.4130S . free .
• Pettersen HS, Sundheim O, Gilljam KM, Slupphaug G, Krokan HE, Kavli B . Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms . Nucleic Acids Research . 35 . 12 . 3879–92 . 2007 . 17537817 . 1919486 . 10.1093/nar/gkm372 .

Notes and References

1. Web site: Entrez Gene: CCNO cyclin O.
2. Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE . Post-replicative base excision repair in replication foci . The EMBO Journal . 18 . 13 . 3834–44 . July 1999 . 10393198 . 1171460 . 10.1093/emboj/18.13.3834 .
3. Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T . A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein . The Journal of Biological Chemistry . 277 . 43 . 40362–7 . October 2002 . 12171929 . 10.1074/jbc.M206194200 . free .