CCNDBP1 explained

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.^[1]

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.^[2]

Interactions

CCNDBP1 has been shown to interact with GRAP2^[3] and Cyclin D1.^[1]

Further reading

• Ma W, Xia X, Stafford LJ . Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. . Oncogene . 25 . 30 . 4207–16 . 2006 . 16501603 . 10.1038/sj.onc.1209450 . etal. 7442061 .
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Chang MS, Chen CY, Yeh HI . Cloning, expression, and genomic organization of mouse mp29 gene . Biochem. Biophys. Res. Commun. . 299 . 2 . 241–6 . 2003 . 12437976 . 10.1016/S0006-291X(02)02605-0 . etal.
• Dgany O, Avidan N, Delaunay J . Congenital Dyserythropoietic Anemia Type I Is Caused by Mutations in Codanin-1 . Am. J. Hum. Genet. . 71 . 6 . 1467–74 . 2003 . 12434312 . 10.1086/344781 . 378595 . etal.
• Terai S, Aoki H, Ashida K, Thorgeirsson SS . Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression . Hepatology . 32 . 2 . 357–66 . 2000 . 10915743 . 10.1053/jhep.2000.9092 . 33459194 .
• Yamada S, Iida T, Tabata T . Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat . Hepatology . 32 . 2 . 278–88 . 2000 . 10915734 . 10.1053/jhep.2000.9604 . etal. free .
• Yao Y, Doki Y, Jiang W . Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins . Exp. Cell Res. . 257 . 1 . 22–32 . 2000 . 10854051 . 10.1006/excr.2000.4884 . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M . GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity . J Biol Chem . 275 . 27 . 20942–8 . Aug 2000 . 10801854 . 10.1074/jbc.M002598200 . free .
2. Web site: Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1.
3. Xia . C . Bao Z. Tabassam F. Ma W. Qiu M. Hua S. Liu M . Jul 2000 . GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity . J. Biol. Chem. . 275 . 27 . 20942–8 . UNITED STATES. 0021-9258. 10801854 . 10.1074/jbc.M002598200 . free .