C-C motif chemokine ligand 27 explained

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene.^[1]

Function

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.^{[2] [3]} CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.^[4] The gene for CCL27 is located on human chromosome 9.^[5] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].

Further reading

• Mackay CR . New avenues for anti-inflammatory therapy . Nature Medicine . 8 . 2 . 117–8 . February 2002 . 11821893 . 10.1038/nm0202-117 . 26588760 .
• Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, Tada Y, Wakugawa M, Watanabe T, Torii H, Komine M, Asahina A, Nakamura K, Tamaki K . 6 . Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris . The Journal of Allergy and Clinical Immunology . 111 . 3 . 592–7 . March 2003 . 12642842 . 10.1067/mai.2003.114 .
• Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E . Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis . The Journal of Allergy and Clinical Immunology . 113 . 2 . 334–40 . February 2004 . 14767451 . 10.1016/j.jaci.2003.12.007 . free .
• Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M . TARC augments TNF-alpha-induced CTACK production in keratinocytes . Experimental Dermatology . 13 . 9 . 551–7 . September 2004 . 15335355 . 10.1111/j.0906-6705.2004.00202.x . 84940084 .
• Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, Yoshie O, Miyasaka M . 6 . Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus . The Journal of Biological Chemistry . 279 . 50 . 51775–82 . December 2004 . 15466853 . 10.1074/jbc.M409868200 . free .
• Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L . Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB . Cytokine . 29 . 2 . 49–55 . January 2005 . 15598438 . 10.1016/j.cyto.2004.09.008 .
• Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, von Blomberg BM, Scheper RJ, Bruynzeel DP, Rustemeyer T, Gibbs S . 6 . Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure . Experimental Dermatology . 14 . 2 . 109–16 . February 2005 . 15679580 . 10.1111/j.0906-6705.2005.00226.x . 8770112 .
• Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, Sasaki K, Asahina A, Tamaki K . 6 . CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27 . Experimental Dermatology . 15 . 2 . 95–100 . February 2006 . 16433680 . 10.1111/j.1600-0625.2005.00390.x . 31590665 .

Notes and References

1. Web site: Entrez Gene: C-C motif chemokine ligand 27. 2018-03-23.
2. Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
3. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A . 6 . CCL27-CCR10 interactions regulate T cell-mediated skin inflammation . Nature Medicine . 8 . 2 . 157–65 . February 2002 . 11821900 . 10.1038/nm0202-157 . 35433583 .
4. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A . 6 . Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) . Journal of Immunology . 164 . 7 . 3465–70 . April 2000 . 10725697 . 10.4049/jimmunol.164.7.3465 . free .
5. Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, Yamada H, Hieshima K, Suzuki R, Nomiyama H, Yoshie O . 6 . Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus . FEBS Letters . 460 . 3 . 544–8 . November 1999 . 10556532 . 10.1016/s0014-5793(99)01406-4 . 39019419 . 1999FEBSL.460..544I .