chemokine (C-C motif) ligand 15 | |
Hgncid: | 10613 |
Symbol: | CCL15 |
Altsymbols: | SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B |
Entrezgene: | 6359 |
Omim: | 601393 |
Refseq: | NM_032965 |
Uniprot: | Q16663 |
Pdb: | 2HCC |
Chromosome: | 17 |
Arm: | q |
Band: | 11.2 |
Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung.[1] It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3.[2] [3] The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14.[4]