CCDC90B explained

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.

Gene

CCDC90B is located on chromosome 11 in humans. It is neighbored by:^[1]

• PCF11, a mammalian pre-mRNA cleavage complex 2 protein
• ANKRD42, ankyrin repeat protein involved with calcium ion bonding
• BC070093
• DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Protein

Structure

This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

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Predicted Properties

Molecular Weight

26.72 kDa

Isoelectric point

7.5

Transmembrane Helices: None

Post-translation modifications

^[2]

Chloroplast transit peptides: None

Signal pepties: None

C-mannosylation sites: None

N-glycosylation sites: None

Mitochondrial targeting: Yes

Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

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Cellular Location

CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.

Notes and References

1. Web site: UCSC Genome Bioinformatics BLAT . 2009-05-14 . March 2006 . University of California - Santa Cruz .
2. Web site: ExPASy . 2009-05-14 . 2009-01-05 . SIB Switzerland .