CCDC85B explained

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.^{[1] [2] [3]}

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.

Interactions

CCDC85B has been shown to interact with:

• C19orf25,
• KIAA1267,^[4]
• Keratin 17,^[4] and
• Protein kinase N1.^[4]

Further reading

• Robertson HD . How did replicating and coding RNAs first get together? . Science . 274 . 5284 . 66–7 . Oct 1996 . 8848724 . 10.1126/science.274.5284.66 . 1996Sci...274...66R . 37715470 .
• Long M, de Souza SJ, Gilbert W . Delta-interacting protein A and the origin of hepatitis delta antigen . Science . 276 . 5313 . 824–5 . May 1997 . 9115212 . 10.1126/science.276.5313.824 .
• Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S . C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage . Cell Death and Differentiation . 12 . 2 . 153–61 . Feb 2005 . 15605074 . 10.1038/sj.cdd.4401539 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Du X, Wang Q, Hirohashi Y, Greene MI . DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription . Experimental and Molecular Pathology . 81 . 3 . 184–90 . Dec 2006 . 17014843 . 10.1016/j.yexmp.2006.07.008 .

Notes and References

1. Brazas R, Ganem D . A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution . Science . 274 . 5284 . 90–4 . Oct 1996 . 8810253 . 10.1126/science.274.5284.90 . 1996Sci...274...90B . 20743492 .
2. Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, Ailhaud G, Amri EZ . Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation . The Journal of Biological Chemistry . 280 . 12 . 11432–8 . Mar 2005 . 15644333 . 10.1074/jbc.M411741200 . free .
3. Web site: Entrez Gene: CCDC85B coiled-coil domain containing 85B.
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .