CCBP2 explained

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.^{[1] [2] [3]}

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Further reading

• Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ . Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. . J. Biol. Chem. . 272 . 19 . 12495–504 . 1997 . 9139699 . 10.1074/jbc.272.19.12495 . free .
• Nibbs RJ, Yang J, Landau NR . LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. . J. Biol. Chem. . 274 . 25 . 17478–83 . 1999 . 10364178 . 10.1074/jbc.274.25.17478 . etal. free .
• Maho A, Bensimon A, Vassart G, Parmentier M . Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. . Cytogenet. Cell Genet. . 87 . 3–4 . 265–8 . 2000 . 10702689 . 10.1159/000015443 . 1178132 .
• Gosling J, Dairaghi DJ, Wang Y . Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. . J. Immunol. . 164 . 6 . 2851–6 . 2000 . 10706668 . 10.4049/jimmunol.164.6.2851. etal. free .
• Jarmin DI, Rits M, Bota D . Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. . J. Immunol. . 164 . 7 . 3460–4 . 2000 . 10725696 . 10.4049/jimmunol.164.7.3460. etal. free .
• Homey B, Wang W, Soto H . Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). . J. Immunol. . 164 . 7 . 3465–70 . 2000 . 10725697 . 10.4049/jimmunol.164.7.3465. etal. free .
• Wang W, Soto H, Oldham ER . Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). . J. Biol. Chem. . 275 . 29 . 22313–23 . 2000 . 10781587 . 10.1074/jbc.M001461200 . etal. free .
• Nibbs RJ, Kriehuber E, Ponath PD . The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. . Am. J. Pathol. . 158 . 3 . 867–77 . 2001 . 11238036 . 10.1016/s0002-9440(10)64035-7. 1850343 . etal.
• Homey B, Alenius H, Müller A . CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. . Nat. Med. . 8 . 2 . 157–65 . 2002 . 11821900 . 10.1038/nm0202-157 . 35433583 . etal.
• Soler D, Humphreys TL, Spinola SM, Campbell JJ . CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. . Blood . 101 . 5 . 1677–82 . 2003 . 12406880 . 10.1182/blood-2002-07-2348 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Fra AM, Locati M, Otero K . Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. . J. Immunol. . 170 . 5 . 2279–82 . 2003 . 12594248 . 10.4049/jimmunol.170.5.2279. etal. free .
• Kunkel EJ, Kim CH, Lazarus NH . CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. . J. Clin. Invest. . 111 . 7 . 1001–10 . 2003 . 12671049 . 10.1172/JCI17244 . 152588 . etal.
• Galliera E, Jala VR, Trent JO . beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. . J. Biol. Chem. . 279 . 24 . 25590–7 . 2004 . 15084596 . 10.1074/jbc.M400363200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Neil SJ, Aasa-Chapman MM, Clapham PR . The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. . J. Virol. . 79 . 15 . 9618–24 . 2005 . 16014924 . 10.1128/JVI.79.15.9618-9624.2005 . 1181543 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.

Notes and References

1. Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF . Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3 . DNA Cell Biol . 16 . 10 . 1249–56 . Dec 1997 . 9364936 . 10.1089/dna.1997.16.1249 .
2. Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ . Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6 . J Biol Chem . 272 . 51 . 32078–83 . Jan 1998 . 9405404 . 10.1074/jbc.272.51.32078 . free .
3. Web site: Entrez Gene: CCBP2 chemokine binding protein 2.