Protein chibby homolog 1 explained

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.^{[1] [2] [3]}

Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

CBY1 has been shown to interact with Beta-catenin.^[4] CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.^[5]

Further reading

• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S . Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes . Genome Res. . 11 . 5 . 677–84 . 2001 . 11337467 . 311086 . 10.1101/gr.gr-1640r.
• Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I . Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22 . Genome Res. . 13 . 1 . 27–36 . 2003 . 12529303 . 430954 . 10.1101/gr.695703 .
• Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT . Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway . Nature . 422 . 6934 . 905–9 . 2003 . 12712206 . 10.1038/nature01570 . 2003Natur.422..905T . 4418716 .
• Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P, Laurent-Puig P . Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? . BMC Cancer . 4 . 31 . 2004 . 15245581 . 471554 . 10.1186/1471-2407-4-31 . free .
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 545604 . 10.1186/gb-2004-5-10-r84 . free .
• Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK . Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines . World J. Gastroenterol. . 12 . 10 . 1529–35 . 2006 . 10.3748/wjg.v12.i10.1529 . 16570344 . 4124284 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .
• Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K . Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling . Mol. Cell. Biol. . 27 . 12 . 4347–54 . 2007 . 17403895 . 1900052 . 10.1128/MCB.01640-06 .

Notes and References

1. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
2. Hidaka S, Könecke V, Osten L, Witzgall R . PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2 . J Biol Chem . 279 . 33 . 35009–16 . Aug 2004 . 15194699 . 10.1074/jbc.M314206200 . free .
3. Web site: Entrez Gene: CBY1 chibby homolog 1 (Drosophila).
4. Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT . Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway . . 422 . 6934 . 905–9 . Apr 2003 . 12712206 . 10.1038/nature01570 . 2003Natur.422..905T . 4418716 .
5. Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI . November 2016 . BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis . Molecular and Cellular Biology . 36 . 21 . 2668–2680 . 10.1128/MCB.00160-16 . 5064215 . 27528616.