CBX8 explained

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.^{[1] [2]}

Interactions

CBX8 has been shown to interact with RING1^[3] and MLLT1.^[4]

Further reading

• García-Cuéllar MP, Zilles O, Schreiner SA . The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. . Oncogene . 20 . 4 . 411–9 . 2001 . 11313972 . 10.1038/sj.onc.1204108 . etal. free .
• Hemenway CS, de Erkenez AC, Gould GC . The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. . Oncogene . 20 . 29 . 3798–805 . 2001 . 11439343 . 10.1038/sj.onc.1204478 . 25138105 .
• Levine SS, Weiss A, Erdjument-Bromage H . The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. . Mol. Cell. Biol. . 22 . 17 . 6070–8 . 2002 . 12167701 . 10.1128/MCB.22.17.6070-6078.2002 . 134016 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Obuse C, Yang H, Nozaki N . Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. . Genes Cells . 9 . 2 . 105–20 . 2004 . 15009096 . 10.1111/j.1365-2443.2004.00705.x . 21813024 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. free . 11858/00-001M-0000-0010-8592-0 . free .
• Dietrich N, Bracken AP, Trinh E . Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. . EMBO J. . 26 . 6 . 1637–48 . 2007 . 17332741 . 10.1038/sj.emboj.7601632 . 1829390 . etal.

Notes and References

1. Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS . HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties . J Biol Chem . 275 . 37 . 28785–92 . Oct 2000 . 10825164 . 10.1074/jbc.M001835200 . free .
2. Web site: Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila).
3. Bárdos . J I . Saurin A J. Tissot C. Duprez E. Freemont P S . Sep 2000 . HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties . J. Biol. Chem. . 275 . 37 . 28785–92 . 0021-9258. 10825164 . 10.1074/jbc.M001835200 . free .
4. García-Cuéllar . M P . Zilles O. Schreiner S A. Birke M. Winkler T H. Slany R K . Jan 2001 . The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 . Oncogene . 20 . 4 . 411–9 . 0950-9232. 11313972 . 10.1038/sj.onc.1204108 . free .