CBX7 (gene) explained

Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene.^[1] The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.^[2]

Further reading

• Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou MM . 6 . Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a . Molecular Cell . 38 . 5 . 662–74 . June 2010 . 20541999 . 2886305 . 10.1016/j.molcel.2010.03.021 .
• Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, Cozzolino M, Keller S, Fedele M, Leone V, Troncone G, Chiariotti L, Pucci P, Fusco A . 6 . Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein . Cancer Research . 69 . 17 . 7079–87 . September 2009 . 19706751 . 10.1158/0008-5472.CAN-09-1542 . free .
• Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, Bianco M, Ferraro A, Sacchetti S, Troncone G, Fusco A, Tornillo L . 6 . The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients . European Journal of Cancer . 46 . 12 . 2304–13 . August 2010 . 20542683 . 10.1016/j.ejca.2010.05.011 .
• Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, Li J, Guo WJ . 6 . Oncogenic role of the chromobox protein CBX7 in gastric cancer . Journal of Experimental & Clinical Cancer Research . 29 . 1 . 114 . August 2010 . 20723236 . 2933612 . 10.1186/1756-9966-29-114 . free .
• Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A . Vertebrate diapause preserves organisms long term through Polycomb complex members . Science . 367 . 6480 . 870–874 . February 2020 . 32079766 . 10.1126/science.aaw2601 . 7532943 . 2020Sci...367..870H .

Notes and References

1. Web site: Chromobox homolog 7. 2011-12-06.
2. Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, Iaccarino A, Russo M, Pierantoni GM, Leone V, Sacchetti S, Troncone G, Santoro M, Fusco A . 6 . Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer . Cancer Research . 68 . 16 . 6770–8 . August 2008 . 18701502 . 10.1158/0008-5472.CAN-08-0695 . free .