CBX1 explained

Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.^{[1] [2]}

Function

The protein is localized at heterochromatin sites, where it mediates gene silencing.

Interactions

CBX1 has been shown to interact with:

• C11orf30,^[3]
• CBX3 and
• CBX5,^[4] and
• SUV39H1.^[5]

See also

• Heterochromatin protein 1

Further reading

• Lessard J, Baban S, Sauvageau G . Stage-specific expression of polycomb group genes in human bone marrow cells . Blood . 91 . 4 . 1216–24 . Feb 1998 . 9454751 . 10.1182/blood.V91.4.1216. free .
• Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T . Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31 . The EMBO Journal . 18 . 7 . 1923–38 . Apr 1999 . 10202156 . 1171278 . 10.1093/emboj/18.7.1923 .
• Minc E, Allory Y, Worman HJ, Courvalin JC, Buendia B . Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells . Chromosoma . 108 . 4 . 220–34 . Aug 1999 . 10460410 . 10.1007/s004120050372 . 12381860 .
• Murzina N, Verreault A, Laue E, Stillman B . Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins . Molecular Cell . 4 . 4 . 529–40 . Oct 1999 . 10549285 . 10.1016/S1097-2765(00)80204-X . free .
• Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R, Gansmuller A, Chambon P, Losson R . Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family . The EMBO Journal . 18 . 22 . 6385–95 . Nov 1999 . 10562550 . 1171701 . 10.1093/emboj/18.22.6385 .
• Brasher SV, Smith BO, Fogh RH, Nietlispach D, Thiru A, Nielsen PR, Broadhurst RW, Ball LJ, Murzina NV, Laue ED . The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer . The EMBO Journal . 19 . 7 . 1587–97 . Apr 2000 . 10747027 . 310228 . 10.1093/emboj/19.7.1587 .
• Zhao T, Heyduk T, Allis CD, Eissenberg JC . Heterochromatin protein 1 binds to nucleosomes and DNA in vitro . The Journal of Biological Chemistry . 275 . 36 . 28332–8 . Sep 2000 . 10882726 . 10.1074/jbc.M003493200 . free .
• Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T . Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins . Nature . 410 . 6824 . 116–20 . Mar 2001 . 11242053 . 10.1038/35065132 . 4331863 .
• Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T . Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain . Nature . 410 . 6824 . 120–4 . Mar 2001 . 11242054 . 10.1038/35065138 . 4334447 .
• Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R . Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins . Molecular Cell . 7 . 4 . 729–39 . Apr 2001 . 11336697 . 10.1016/S1097-2765(01)00218-0 . free . 10261/308369 . free .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Current Biology . 12 . 1 . 1–11 . Jan 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Scholzen T, Endl E, Wohlenberg C, van der Sar S, Cowell IG, Gerdes J, Singh PB . The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure . The Journal of Pathology . 196 . 2 . 135–44 . Feb 2002 . 11793364 . 10.1002/path.1016 . 36130549 .
• Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV, Laue ED . Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 . Nature . 416 . 6876 . 103–7 . Mar 2002 . 11882902 . 10.1038/nature722 . 2002Natur.416..103N . 4423019 .
• Vassallo MF, Tanese N . Isoform-specific interaction of HP1 with human TAFII130 . Proceedings of the National Academy of Sciences of the United States of America . 99 . 9 . 5919–24 . Apr 2002 . 11959914 . 122877 . 10.1073/pnas.092025499 . 2002PNAS...99.5919V . free .
• Hwang KK, Worman HJ . Gene regulation by human orthologs of Drosophila heterochromatin protein 1 . Biochemical and Biophysical Research Communications . 293 . 4 . 1217–22 . May 2002 . 12054505 . 10.1016/S0006-291X(02)00377-7 .
• Bhattacharya N, Wang Z, Davitt C, McKenzie IF, Xing PX, Magnuson NS . Pim-1 associates with protein complexes necessary for mitosis . Chromosoma . 111 . 2 . 80–95 . Jul 2002 . 12111331 . 10.1007/s00412-002-0192-6 . 26016943 .
• Lin CY, Li CC, Huang PH, Lee FJ . A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1 . Journal of Cell Science . 115 . Pt 23 . 4433–45 . Dec 2002 . 12414990 . 10.1242/jcs.00123 . 16851984 .
• Festenstein R, Pagakis SN, Hiragami K, Lyon D, Verreault A, Sekkali B, Kioussis D . Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells . Science . 299 . 5607 . 719–21 . Jan 2003 . 12560554 . 10.1126/science.1078694 . 2003Sci...299..719F . 26661977 .

Notes and References

1. Furuta K, Chan EK, Kiyosawa K, Reimer G, Luderschmidt C, Tan EM . Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis . Chromosoma . 106 . 1 . 11–9 . Jun 1997 . 9169582 . 10.1007/s004120050219 . 33460511 .
2. Web site: Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila).
3. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T . EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer . Cell . 115 . 5 . 523–35 . Nov 2003 . 14651845 . 10.1016/s0092-8674(03)00930-9. 18911371 . free .
4. Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R . Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins . Molecular Cell . 7 . 4 . 729–39 . Apr 2001 . 11336697 . 10.1016/S1097-2765(01)00218-0. free . 10261/308369 . free .
5. Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T . Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31 . The EMBO Journal . 18 . 7 . 1923–38 . Apr 1999 . 10202156 . 1171278 . 10.1093/emboj/18.7.1923 .