CBR3 explained

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.^{[1] [2] [3]}

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.

Further reading

• Wermuth B, Mäder-Heinemann G, Ernst E . Cloning and expression of carbonyl reductase from rat testis. . Eur. J. Biochem. . 228 . 2 . 473–9 . 1995 . 7705364 . 10.1111/j.1432-1033.1995.tb20286.x . 2024-05-07 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Dahmane N, Ghezala GA, Gosset P . Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. . Genomics . 48 . 1 . 12–23 . 1998 . 9503011 . 10.1006/geno.1997.5146 . etal.
• Ismail E, Al-Mulla F, Tsuchida S . Carbonyl reductase: a novel metastasis-modulating function. . Cancer Res. . 60 . 5 . 1173–6 . 2000 . 10728668 . etal.
• Hattori M, Fujiyama A, Taylor TD . The DNA sequence of human chromosome 21. . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . etal. free .
• Umemoto M, Yokoyama Y, Sato S . Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer. . Br. J. Cancer . 85 . 7 . 1032–6 . 2001 . 11592776 . 10.1038/sj.bjc.6692034 . 2375107 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Lakhman SS, Ghosh D, Blanco JG . Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). . Drug Metab. Dispos. . 33 . 2 . 254–7 . 2005 . 15537833 . 10.1124/dmd.104.002006 . 18027092 .

Notes and References

1. Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T . Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2 . Genomics . 52 . 1 . 95–100 . May 1999 . 9740676 . 10.1006/geno.1998.5380 .
2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chem Biol Interact . 178 . 1–3 . 94–8 . Feb 2009 . 19027726 . 2896744. 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
3. Web site: Entrez Gene: CBR3 carbonyl reductase 3.