CBLC explained

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.^{[1] [2] [3]}

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]

Interactions

CBLC has been shown to interact with FYN^[4] and Epidermal growth factor receptor.^{[2] [5]}

Further reading

• Ollendorff V, Mattei M, Fournier E . A third human CBL gene is on chromosome 19 . Int. J. Oncol. . 13 . 6 . 1159–61 . 1999 . 9824625 . 10.3892/ijo.13.6.1159. etal.
• Irby RB, Mao W, Coppola D . Activating SRC mutation in a subset of advanced human colon cancers . Nat. Genet. . 21 . 2 . 187–90 . 1999 . 9988270 . 10.1038/5971 . 27129630 . etal.
• Ettenberg SA, Keane MM, Nau MM . Cbl-b inhibits epidermal growth factor receptor signaling . Oncogene . 18 . 10 . 1855–66 . 1999 . 10086340 . 10.1038/sj.onc.1202499 . etal. free .
• Loreto MP, Berry DM, McGlade CJ . Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling . Mol. Cell. Biol. . 22 . 12 . 4241–55 . 2002 . 12024036 . 10.1128/MCB.22.12.4241-4255.2002 . 133880 .
• Szymkiewicz I, Kowanetz K, Soubeyran P . CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases . J. Biol. Chem. . 277 . 42 . 39666–72 . 2002 . 12177062 . 10.1074/jbc.M205535200 . etal. free .
• Courbard JR, Fiore F, Adélaïde J . Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH . J. Biol. Chem. . 277 . 47 . 45267–75 . 2003 . 12226085 . 10.1074/jbc.M206460200 . etal. free .
• Wong ES, Fong CW, Lim J . Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling . EMBO J. . 21 . 18 . 4796–808 . 2002 . 12234920 . 10.1093/emboj/cdf493 . 126289 . etal.
• Taher TE, Tjin EP, Beuling EA . C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination . J. Immunol. . 169 . 7 . 3793–800 . 2002 . 12244174 . 10.4049/jimmunol.169.7.3793. etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Nau MM, Lipkowitz S . Comparative genomic organization of the cbl genes . Gene . 308 . 103–13 . 2003 . 12711395 . 10.1016/S0378-1119(03)00471-2 .
• Kim M, Tezuka T, Tanaka K, Yamamoto T . Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation . Oncogene . 23 . 9 . 1645–55 . 2004 . 14661060 . 10.1038/sj.onc.1207298 . 24925646 .
• Kassenbrock CK, Anderson SM . Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations . J. Biol. Chem. . 279 . 27 . 28017–27 . 2004 . 15117950 . 10.1074/jbc.M404114200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .

Notes and References

1. Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S . cbl-3: a new mammalian cbl family protein . Oncogene . 18 . 22 . 3365–75 . Jun 1999 . 10362357 . 10.1038/sj.onc.1202753 . 28195948 .
2. Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T . Molecular cloning and characterization of a novel cbl-family gene, cbl-c . Gene . 239 . 1 . 145–54 . Dec 1999 . 10571044 . 10.1016/S0378-1119(99)00356-X .
3. Web site: Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c.
4. Kim . M . Tezuka T. Suziki Y. Sugano S. Hirai M. Yamamoto T . Oct 1999 . Molecular cloning and characterization of a novel cbl-family gene, cbl-c . Gene . 239 . 1 . 145–54 . NETHERLANDS. 0378-1119. 10571044 . 10.1016/S0378-1119(99)00356-X .
5. Keane . M M . Ettenberg S A. Nau M M. Banerjee P. Cuello M. Penninger J. Lipkowitz S . Jun 1999 . cbl-3: a new mammalian cbl family protein . Oncogene . 18 . 22 . 3365–75 . ENGLAND. 0950-9232. 10362357 . 10.1038/sj.onc.1202753 . 28195948 .