CB-13 explained

CB-13 (CRA13, SAB-378)[1] is a cannabinoid drug, which acts as a potent agonist at both the CB1 and CB2 receptors, but has poor blood–brain barrier penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as catalepsy only appearing at much higher dose ranges. It has antihyperalgesic properties in animal studies,[2] and has progressed to preliminary human trials.[3]

Legal Status

As of October 2015 CB-13 is a controlled substance in China.[4]

CB-13 is a Schedule I controlled substance in North Dakota.[5]

See also

Notes and References

  1. Cluny NL, Keenan CM, Duncan M, Fox A, Lutz B, Sharkey KA . Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice . The Journal of Pharmacology and Experimental Therapeutics . 334 . 3 . 973–980 . September 2010 . 20571060 . 10.1124/jpet.110.169946 . 9198992 .
  2. Dziadulewicz EK, Bevan SJ, Brain CT, Coote PR, Culshaw AJ, Davis AJ, Edwards LJ, Fisher AJ, Fox AJ, Gentry C, Groarke A, Hart TW, Huber W, James IF, Kesingland A, La Vecchia L, Loong Y, Lyothier I, McNair K, O'Farrell C, Peacock M, Portmann R, Schopfer U, Yaqoob M, Zadrobilek J . 6 . Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration . Journal of Medicinal Chemistry . 50 . 16 . 3851–3856 . August 2007 . 17630726 . 10.1021/jm070317a .
  3. Gardin A, Kucher K, Kiese B, Appel-Dingemanse S . Cannabinoid receptor agonist 13, a novel cannabinoid agonist: first in human pharmacokinetics and safety . Drug Metabolism and Disposition . 37 . 4 . 827–833 . April 2009 . 19144772 . 10.1124/dmd.108.024000 . 15150118 .
  4. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . Notice on Printing and Distributing the "Measures for the Scheduling of Non-Pharmaceutical Narcotic Drugs and Psychotropic Substances" . China Food and Drug Administration . 27 September 2015 . zh . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .
  5. Web site: Schedule 1 . Sixty-eighth Legislative Assembly of North Dakota. 3 January 2023 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CB-13".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.