Tumor-associated glycoprotein 72 explained
Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary,[1] [2] [3] breast, colon,[4] lung, and pancreatic cancers.[5] [6] It is a mucin-like molecule with a molar mass of over 1000 kDa.[7]
TAG-72 is a tumor marker measured with radioimmunoassays like CA 72-4, which uses the monoclonal antibodies indium (111In) satumomab pendetide and iodine (125I) minretumomab.[8] [9] [10] [11] [12] This assay has a good specificity for gastric cancer, with a correlation to the neoplasia's extension. It is used to identify relapses of the disease and to follow up the treatment.
TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox and minretumomab.
Notes and References
- Ponnusamy MP, Venkatraman G, Singh AP, Chauhan SC, Johansson SL, Jain M, Smith L, Davis JS, Remmenga SW, Batra SK. Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis. Cancer Lett. 2007 Jun 28;251(2):247-57. doi: 10.1016/j.canlet.2006.11.025. Epub 2007 Jan 8. PMID: 17210225.
- Murad JP, Kozlowska AK, Lee HJ, Ramamurthy M, Chang WC, Yazaki P, Colcher D, Shively J, Cristea M, Forman SJ, Priceman SJ. Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells. Front Immunol. 2018 Nov 19;9:2268. doi: 10.3389/fimmu.2018.02268. PMID: 30510550; PMCID: PMC6254427.
- Shu R, Evtimov VJ, Hammett MV, Nguyen NN, Zhuang J, Hudson PJ, Howard MC, Pupovac A, Trounson AO, Boyd RL. Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer. Mol Ther Oncolytics. 2021 Jan 16;20:325-341. doi: 10.1016/j.omto.2021.01.002. PMID: 33614914; PMCID: PMC7868933.
- Hege KM, Bergsland EK, Fisher GA, Nemunaitis JJ, Warren RS, McArthur JG, Lin AA, Schlom J, June CH, Sherwin SA. Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer. J Immunother Cancer. 2017 Mar 21;5:22. doi: 10.1186/s40425-017-0222-9. PMID: 28344808; PMCID: PMC5360066.
- http://www.cancer.gov/dictionary?CdrID=45925 TAG-72 antigen
- 10.1038/nrc3236. 22437872. Antibody therapy of cancer. Nature Reviews Cancer. 12. 4. 278–87. 2012. Scott. Andrew M.. Wolchok. Jedd D.. Old. Lloyd J.. 205469234.
- Sheer. Donald G.. Purification and Composition of the Human Tumor-associated Glycoprotein (TAG-72) Defined by Monoclonal Antibodies CC49 and B72.3. Cancer Research. 48. 6811–6818. 1988. 3180090. Schlom. J. Cooper. HL. 23.
- Louhimo J, Alfthan H, Stenman UH, Haglund C . Serum HCG beta and CA 72-4 are stronger prognostic factors than CEA, CA 19-9 and CA 242 in pancreatic cancer . Oncology . 66 . 2 . 126–31 . 2004 . 15138364 . 10.1159/000077438 . 25798287 .
- Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C . Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer . Int. J. Cancer . 101 . 6 . 545–8 . October 2002 . 12237895 . 10.1002/ijc.90009. free .
- Louhimo J, Kokkola A, Alfthan H, Stenman UH, Haglund C . Preoperative hCGbeta and CA 72-4 are prognostic factors in gastric cancer . Int. J. Cancer . 111 . 6 . 929–33 . October 2004 . 15300805 . 10.1002/ijc.20321. 24698852 . free .
- Mattar R, Alves de Andrade CR, DiFavero GM, Gama-Rodrigues JJ, Laudanna AA . Preoperative serum levels of CA 72-4, CEA, CA 19-9, and alpha-fetoprotein in patients with gastric cancer . Rev Hosp Clin Fac Med Sao Paulo . 57 . 3 . 89–92 . 2002 . 12118264 . 10.1590/s0041-87812002000300001. free .
- Guadagni F, Roselli M, Cosimelli M, etal . Correlation between tumor-associated glycoprotein 72 mucin levels in tumor and serum of colorectal patients as measured by the quantitative CA 72-4 immunoassay . Cancer Res. . 56 . 22 . 5293–8 . November 1996 . 8912871 .