| State: | CA |
| Type: | SR |
| Route: | 216 |
| Map Notes: | Map of Tulare County in central California with SR 216 highlighted in red |
| Section: | 516 |
| Maint: | Caltrans |
| Length Mi: | 18.275 |
| Length Round: | 3 |
| Direction A: | West |
| Terminus A: | in Visalia |
| Direction B: | East |
| Terminus B: | near Woodlake |
| Counties: | Tulare |
| Previous Type: | I |
| Previous Route: | 215 |
| Next Type: | SR |
| Next Route: | 217 |
State Route 216 (SR 216) is a state highway in the U.S. state of California. It is a loop of State Route 198 in Tulare County, running from Visalia to Ivanhoe and Woodlake.
The route begins at State Route 198 in Visalia with an interchange. It then continues to Ivanhoe, where it meets County Route J34. As it continues through Tulare County, it enters Woodlake, where it meets State Route 245. It then meets County Route J21 before meeting its north end at State Route 198.
The portion of SR 216 in the Visalia city limits is part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration.