CatSper2 explained

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.^{[1] [2]} CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[3]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.^[4]

See also

• Pseudogene (database)

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhang D, Chen J, Saraf A . Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. . J. Biol. Chem. . 281 . 31 . 22332–41 . 2006 . 16740636 . 10.1074/jbc.M511288200 . etal. free .
• Garbers DL . Ion channels. Swimming with sperm. . Nature . 413 . 6856 . 579, 581–2 . 2001 . 11595929 . 10.1038/35098164 . 2001Natur.413..579G . 6099942 .
• Quill TA, Ren D, Clapham DE, Garbers DL . A voltage-gated ion channel expressed specifically in spermatozoa. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 22 . 12527–31 . 2001 . 11675491 . 10.1073/pnas.221454998 . 60087 . 2001PNAS...9812527Q . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Clapham DE, Garbers DL . International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. . Pharmacol. Rev. . 57 . 4 . 451–4 . 2005 . 16382101 . 10.1124/pr.57.4.7 . 35096827 .

Notes and References

1. Quill TA, Ren D, Clapham DE, Garbers DL . A voltage-gated ion channel expressed specifically in spermatozoa . Proc. Natl. Acad. Sci. U.S.A. . 98 . 22 . 12527–31 . October 2001 . 11675491 . 60087 . 10.1073/pnas.221454998 . 2001PNAS...9812527Q . free .
2. Clapham DE, Garbers DL . International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels . Pharmacol. Rev. . 57 . 4 . 451–4 . December 2005 . 16382101 . 10.1124/pr.57.4.7 . 35096827 .
3. • Web site: CatSper and Two-Pore Channels: Introduction . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .
4. Web site: Entrez Gene: CatSper2 .