CASP8AP2 explained

CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.^{[1] [2] [3] [4]}

Function

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Researches of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex, that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.

Interactions

CASP8AP2 has been shown to interact with TRAF2.^[5]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2002 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM . Apoptosis. Searching for FLASH domains . Nature . 401 . 6754 . 662; discussion 662–3 . 1999 . 10537104 . 10.1038/44317 . 1999Natur.401Q.662K . 4390408 . free .
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
• Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK . FLASH coordinates NF-kappa B activity via TRAF2 . J. Biol. Chem. . 276 . 27 . 25073–7 . 2001 . 11340079 . 10.1074/jbc.M102941200 . free .
• Kino T, Chrousos GP . Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators . J. Biol. Chem. . 278 . 5 . 3023–9 . 2003 . 12477726 . 10.1074/jbc.M209234200 . free .
• Jun JI, Chung CW, Lee HJ, Pyo JO, Lee KN, Kim NS, Kim YS, Yoo HS, Lee TH, Kim E, Jung YK . Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway . Oncogene . 24 . 4 . 688–96 . 2005 . 15592525 . 10.1038/sj.onc.1208186 . 12720899 .
• Kino T, Ichijo T, Chrousos GP . FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors . J. Steroid Biochem. Mol. Biol. . 92 . 5 . 357–63 . 2004 . 15698540 . 10.1016/j.jsbmb.2004.09.003 . 41799122 .
• Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui CH, Downing JR, Campana D . Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2 . Blood . 108 . 3 . 1050–7 . 2006 . 16627760 . 1895863 . 10.1182/blood-2006-01-0322 .
• Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V . FLASH is required for histone transcription and S-phase progression . Proc. Natl. Acad. Sci. U.S.A. . 103 . 40 . 14808–12 . 2006 . 17003125 . 1578501 . 10.1073/pnas.0604227103 . 2006PNAS..10314808B . free .
• Jeong EG, Lee SH, Lee HW, Soung YH, Yoo NJ, Lee SH . Immunohistochemical and mutational analysis of FLASH in gastric carcinomas . APMIS . 115 . 8 . 900–5 . 2007 . 17696945 . 10.1111/j.1600-0463.2007.apm_706.x . 25074994 .

Notes and References

1. Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S . The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis . Nature . 398 . 6730 . 777–85 . Jun 1999 . 10235259 . 10.1038/19709 . 1999Natur.398..777I . 2792230 .
2. Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG . FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies . EMBO J. . 26 . 2 . 391–401 . Jan 2007 . 17245429 . 1783462 . 10.1038/sj.emboj.7601504 .
3. Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V . FLASH is an essential component of Cajal bodies . Proc. Natl. Acad. Sci. U.S.A. . 103 . 40 . 14802–7 . Oct 2006 . 17003126 . 1578500 . 10.1073/pnas.0604225103 . 2006PNAS..10314802B . free .
4. Web site: Entrez Gene: CASP8AP2 CASP8 associated protein 2.
5. Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK . FLASH coordinates NF-kappa B activity via TRAF2 . J. Biol. Chem. . 276 . 27 . 25073–7 . Jul 2001 . 11340079 . 10.1074/jbc.M102941200 . free .