Caspase recruitment domain-containing protein 8 explained

Caspase recruitment domain-containing protein 8 is a protein that in humans is encoded by the CARD8 gene.^{[1] [2] [3]}

Function

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.^[3]

Further reading

• Fontalba A, Martinez-Taboada V, Gutierrez O . Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. . J. Immunol. . 179 . 7 . 4867–73 . 2007 . 17878386 . 10.4049/jimmunol.179.7.4867. etal. free .
• Franke A, Rosenstiel P, Balschun T . No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample. . Gastroenterology . 132 . 5 . 2080–1 . 2007 . 17484912 . 10.1053/j.gastro.2007.03.087 . etal.
• McGovern DP, Butler H, Ahmad T . TUCAN (CARD8) genetic variants and inflammatory bowel disease. . Gastroenterology . 131 . 4 . 1190–6 . 2006 . 17030188 . 10.1053/j.gastro.2006.08.008 . etal. free .
• Checinska A, Giaccone G, Hoogeland BS . TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells. . BMC Cancer . 6. 166 . 2006 . 16796750 . 10.1186/1471-2407-6-166 . 1538619 . etal . free .
• Agostini L, Martinon F, Burns K . NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. . Immunity . 20 . 3 . 319–25 . 2004 . 15030775 . 10.1016/S1074-7613(04)00046-9 . etal. free .
• Stilo R, Leonardi A, Formisano L . TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. . FEBS Lett. . 521 . 1–3 . 165–9 . 2002 . 12067710 . 10.1016/S0014-5793(02)02869-7 . 21781671 . etal. free .
• Zhang H, Fu W . NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation . Int. J. Oncol. . 20 . 5 . 1035–40 . 2002 . 11956601 . 10.3892/ijo.20.5.1035.
• Razmara M, Srinivasula SM, Wang L . CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis . J. Biol. Chem. . 277 . 16 . 13952–8 . 2002 . 11821383 . 10.1074/jbc.M107811200 . etal. free .
• Bouchier-Hayes L, Conroy H, Egan H . CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways . J. Biol. Chem. . 276 . 47 . 44069–77 . 2001 . 11551959 . 10.1074/jbc.M107373200 . etal. free .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 6 . 1 . 63–70 . Jul 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
2. Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC . TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer . J Biol Chem . 276 . 34 . 32220–9 . Aug 2001 . 11408476 . 10.1074/jbc.M100433200 . free .
3. Web site: Entrez Gene: CARD8 caspase recruitment domain family, member 8.