CAR-302,282 explained

CAR-302,282 (302282, NSC-263548, α-(3-Methylbut-1-yn-3-enyl)mandelic acid 1-methyl-4-piperidyl ester) is an anticholinergic deliriant drug,^{[1] [2]} invented under contract to Edgewood Arsenal in the 1960s. It is a potent incapacitating agent with an ED₅₀ of 1.2μg/kg and a high central to peripheral effects ratio, and a relatively short duration of action compared to other similar drugs of around 6-10 hours. Despite its favorable properties it was relatively little researched compared to more high profile compounds from the series such as EA-3167 and EA-3580.^[3]

See also

• CAR-226,086
• CAR-301,060
• CAR-302,196

Notes and References

1. Baumgold J, Abood LG, Aronstam R . Studies on the relationship of binding affinity to psychoactive and anticholingergic potency of a group of psychotomimetic glycolates . Brain Research . 124 . 2 . 331–40 . March 1977 . 843950 . 10.1016/0006-8993(77)90889-7 . 35326203 .
2. Anticholinergic Drugs. . Baum BM, Stange H . US . 4465834 . 14 August 1984 .
3. Book: Ketchum JS . Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. . ChemBooks Inc . 320-326. 2006 . 978-1-4243-0080-8 .