CAP1 explained

Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene.^{[1] [2] [3]}

The protein encoded by this gene is related to the Saccharomyces cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin.

Interactions

CAP1 has been shown to interact with ACTG1^[4] and CAP2.^[2]

See also

• Adenylyl cyclase

Further reading

• Yu G, Swiston J, Young D . Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins . J. Cell Sci. . 107 . 6. 1671–8 . 1994 . 10.1242/jcs.107.6.1671 . 7962207 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Moriyama K, Yahara I . Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover . J. Cell Sci. . 115 . Pt 8 . 1591–601 . 2003 . 10.1242/jcs.115.8.1591 . 11950878 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Dodatko T, Fedorov AA, Grynberg M . Crystal structure of the actin binding domain of the cyclase-associated protein . Biochemistry . 43 . 33 . 10628–41 . 2004 . 15311924 . 10.1021/bi049071r . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Fautsch MP, Vrabel AM, Johnson DH . The identification of myocilin-associated proteins in the human trabecular meshwork . Exp. Eye Res. . 82 . 6 . 1046–52 . 2006 . 16289162 . 10.1016/j.exer.2005.09.016 .
• Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . etal. 2006Natur.441..315G . free .
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F . Phosphoproteomic analysis of the human pituitary . Pituitary . 9 . 2 . 109–20 . 2006. 16807684 . 10.1007/s11102-006-8916-x . 10789246 .
• Garewal G, Das R, Awasthi A . The clinical significance of the spectrum of interactions of CAP+1 (A-->C), a silent beta-globin gene mutation, with other beta-thalassemia mutations and globin gene modifiers in north Indians . Eur. J. Haematol. . 79 . 5 . 417–21 . 2007 . 17900295 . 10.1111/j.1600-0609.2007.00958.x . 46630115 . etal.

Notes and References

1. Matviw H, Yu G, Young D . Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins . Mol Cell Biol . 12 . 11 . 5033–40 . Nov 1992 . 1406678 . 360436 . 10.1128/mcb.12.11.5033.
2. Hubberstey A, Yu G, Loewith R, Lakusta C, Young D . Mammalian CAP interacts with CAP, CAP2, and actin . J Cell Biochem . 61 . 3 . 459–66 . Apr 1997 . 8761950 . 10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E . 46076387 .
3. Web site: Entrez Gene: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast).
4. Hubberstey . A . Yu G . Loewith R . Lakusta C . Young D . Jun 1996 . Mammalian CAP interacts with CAP, CAP2, and actin . J. Cell. Biochem. . 61 . 3 . 459–66 . UNITED STATES. 0730-2312. 8761950 . 10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E . 46076387 .