Capping protein (actin filament) muscle Z-line, alpha 1 explained

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.^{[1] [2] [3]}

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.^[3] This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Maun NA, Speicher DW, DiNubile MJ, Southwick FS . Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes. . Biochemistry . 35 . 11 . 3518–24 . 1996 . 8639502 . 10.1021/bi952470p .
• Hart MC, Korshunova YO, Cooper JA . Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. . Cell Motil. Cytoskeleton . 38 . 2 . 120–32 . 1997 . 9331217 . 10.1002/(SICI)1097-0169(1997)38:2<120::AID-CM2>3.0.CO;2-B .
• Kuhlman PA, Fowler VM . Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin. . Biochemistry . 36 . 44 . 13461–72 . 1997 . 9354614 . 10.1021/bi970601b .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Osterloh D, Ivanenkov VV, Gerke V . Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization. . Cell Calcium . 24 . 2 . 137–51 . 1999 . 9803314 . 10.1016/S0143-4160(98)90081-1 .
• Inman KG, Yang R, Rustandi RR . Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. . J. Mol. Biol. . 324 . 5 . 1003–14 . 2003 . 12470955 . 10.1016/S0022-2836(02)01152-X . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• McClintock KA, Shaw GS . A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. . J. Biol. Chem. . 278 . 8 . 6251–7 . 2003 . 12480931 . 10.1074/jbc.M210622200 . free .
• Taoka M, Ichimura T, Wakamiya-Tsuruta A . V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein. . J. Biol. Chem. . 278 . 8 . 5864–70 . 2003 . 12488317 . 10.1074/jbc.M211509200 . etal. free .
• Hutchings NJ, Clarkson N, Chalkley R . Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. . J. Biol. Chem. . 278 . 25 . 22396–403 . 2003 . 12690097 . 10.1074/jbc.M302540200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Bruneel A, Labas V, Mailloux A . Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. . Proteomics . 5 . 15 . 3876–84 . 2006 . 16130169 . 10.1002/pmic.200401239 . 26007149 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Canton DA, Olsten ME, Niederstrasser H . The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein. . J. Biol. Chem. . 281 . 47 . 36347–59 . 2007 . 16987810 . 2583070 . 10.1074/jbc.M607595200 . etal. free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 . etal.

Notes and References

1. Barron-Casella EA, Torres MA, Scherer SW, Heng HH, Tsui LC, Casella JF . Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families . J Biol Chem . 270 . 37 . 21472–9 . Oct 1995 . 7665558 . 10.1074/jbc.270.37.21472. free.
2. Hart MC, Korshunova YO, Cooper JA . Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes . Genomics . 39 . 3 . 264–70 . Apr 1997 . 9119363 . 10.1006/geno.1996.4506 .
3. Web site: Entrez Gene: CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1.