Calcyphosin Explained

Calcyphosin is a protein that in humans is encoded by the CAPS gene.^{[1] [2] [3]}

Function

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.

Further reading

• Lefort A, Lecocq R, Libert F . Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid. . EMBO J. . 8 . 1 . 111–6 . 1989 . 2540953 . 10.1002/j.1460-2075.1989.tb03354.x. 400778 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Clément S, Dumont JE, Schurmans S . Loss of calcyphosine gene expression in mouse and other rodents. . Biochem. Biophys. Res. Commun. . 232 . 2 . 407–13 . 1997 . 9125191 . 10.1006/bbrc.1997.6297 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Grimwood J, Gordon LA, Olsen A . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. El Housni H, Radulescu A, Lecocq R, Dumont JE, Christophe D . Cloning and sequence analysis of human calcyphosine complementary DNA . Biochim Biophys Acta . 1352 . 3 . 249–52 . Aug 1997 . 9224948 . 10.1016/s0167-4781(97)00073-0.
2. Lefort A, Passage E, Libert F, Szpirer J, Vassart G, Mattei MG . Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization . Cytogenet Cell Genet . 54 . 3–4 . 154–5 . Feb 1991 . 2265558 . 10.1159/000132981 .
3. Web site: Entrez Gene: CAPS calcyphosine.