CAPRIN2 explained

caprin family member 2, also known as CAPRIN2, is a human gene.^[1]

The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene.^[1]

Further reading

• Aerbajinai W, Lee YT, Wojda U . Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. . J. Biol. Chem. . 279 . 3 . 1916–21 . 2004 . 14593112 . 10.1074/jbc.M305634200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Shiina N, Tokunaga M . RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. . J. Biol. Chem. . 285 . 31 . 24260–9 . 2010 . 20516077 . 10.1074/jbc.M110.108944 . 2911287. free .
• Tao WA, Wollscheid B, O'Brien R . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. . Nat. Methods . 2 . 8 . 591–8 . 2005 . 16094384 . 10.1038/nmeth776 . 20475874 . etal.
• Nagase T, Nakayama M, Nakajima D . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 8 . 2 . 85–95 . 2001 . 11347906 . 10.1093/dnares/8.2.85. etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Ding Y, Xi Y, Chen T . Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. . J. Cell Biol. . 182 . 5 . 865–72 . 2008 . 18762581 . 10.1083/jcb.200803147 . 2528581. etal.
• Grill B, Wilson GM, Zhang KX . Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. . J. Immunol. . 172 . 4 . 2389–400 . 2004 . 14764709 . 10.4049/jimmunol.172.4.2389. etal. free .

Notes and References

1. Web site: Entrez Gene: caprin family member 2. 2011-08-30.