CAPN5 explained

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.^{[1] [2] [3]}

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.

Further reading

• Vanderklish PW, Bahr BA . The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states . International Journal of Experimental Pathology . 81 . 5 . 323–39 . 2001 . 11168679 . 10.1111/j.1365-2613.2000.00169.x . 2517738.
• Sato K, Kawashima S . Calpain function in the modulation of signal transduction molecules . Biol. Chem. . 382 . 5 . 743–51 . 2002 . 11517927 . 10.1515/BC.2001.090 . 882390 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Dear N, Matena K, Vingron M, Boehm T . A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution . Genomics . 45 . 1 . 175–84 . 1997 . 9339374 . 10.1006/geno.1997.4870 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Waghray A, Wang DS, McKinsey D . Molecular cloning and characterization of rat and human calpain-5 . Biochem. Biophys. Res. Commun. . 324 . 1 . 46–51 . 2004 . 15464980 . 10.1016/j.bbrc.2004.09.012 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• González A, Sáez ME, Aragón MJ . Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome . Hum. Reprod. . 21 . 4 . 943–51 . 2006 . 16396936 . 10.1093/humrep/dei443 . etal. free .
• Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R . Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels . BMC Med. Genet. . 8. 1 . 2007 . 17227582 . 10.1186/1471-2350-8-1 . 1783645 . etal . free .

External links

• The MEROPS online database for peptidases and their inhibitors: C02.011

Notes and References

1. Matena K, Boehm T, Dear N . Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily . Genomics . 48 . 1 . 117–20 . Apr 1998 . 9503024 . 10.1006/geno.1997.5133 .
2. Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M . Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene . Biochem Biophys Res Commun . 239 . 3 . 845–50 . Dec 1997 . 9367857 . 10.1006/bbrc.1997.7571 .
3. Web site: Entrez Gene: CAPN5 calpain 5.