CANT1 explained

CANT1 is a gene that encodes soluble calcium-activated nucleotidase 1, an enzyme, in humans.^{[1] [2]}

Further reading

• Smith TM, Hicks-Berger CA, Kim S, Kirley TL . Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases. . Arch. Biochem. Biophys. . 406 . 1 . 105–15 . 2002 . 12234496 . 10.1016/S0003-9861(02)00420-4 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Murphy DM, Ivanenkov VV, Kirley TL . Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase. . Biochemistry . 42 . 8 . 2412–21 . 2003 . 12600208 . 10.1021/bi026763b .
• Matsuda A, Suzuki Y, Honda G . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Dai J, Liu J, Deng Y . Structure and protein design of a human platelet function inhibitor. . Cell . 116 . 5 . 649–59 . 2004 . 15006348 . 10.1016/S0092-8674(04)00172-2 . 15305441 . etal. free .
• Yang M, Kirley TL . Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change. . Biochemistry . 43 . 28 . 9185–94 . 2004 . 15248776 . 10.1021/bi049565o .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .

Notes and References

1. Failer BU, Braun N, Zimmermann H . Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase . J Biol Chem . 277 . 40 . 36978–86 . Sep 2002 . 12167635 . 10.1074/jbc.M201656200 . free .
2. Web site: Entrez Gene: CANT1 calcium activated nucleotidase 1.